Literature DB >> 17218104

Benzoic acid and pyridine derivatives as inhibitors of Trypanosoma cruzi trans-sialidase.

João Neres1, Pascal Bonnet, Philip N Edwards, Pravin L Kotian, Alejandro Buschiazzo, Pedro M Alzari, Richard A Bryce, Kenneth T Douglas.   

Abstract

Benzoic acid and pyridine derivatives inhibit recombinant trans-sialidase from Trypanosoma cruzi with I50 values between 0.4 and 1mM. The best compounds, 4-acetylamino-3-hydroxymethylbenzoic acid and 5-acetylamino-6-aminopyridine-2-carboxylic acid, provide new leads to inhibitors not containing the synthetically complex sialic acid structure. The weak inhibition by such compounds contrasts with their much stronger inhibition of neuraminidase from Influenza virus.

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Year:  2006        PMID： 17218104     DOI： 10.1016/j.bmc.2006.12.024

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  9 in total

1.  Design of e-pharmacophore models using compound fragments for the trans-sialidase of Trypanosoma cruzi: screening for novel inhibitor scaffolds.

Authors:  Bill R Miller; Adrian E Roitberg
Journal:  J Mol Graph Model       Date:  2013-08-16       Impact factor: 2.518

2.  Sialic acid: a sweet swing between mammalian host and Trypanosoma cruzi.

Authors:  Leonardo Freire-de-Lima; Isadora A Oliveira; Jorge L Neves; Luciana L Penha; Frederico Alisson-Silva; Wagner B Dias; Adriane R Todeschini
Journal:  Front Immunol       Date:  2012-11-29       Impact factor: 7.561

Review 3.  Challenges in the chemotherapy of Chagas disease: Looking for possibilities related to the differences and similarities between the parasite and host.

Authors:  Vitor Sueth-Santiago; Debora Decote-Ricardo; Alexandre Morrot; Celio Geraldo Freire-de-Lima; Marco Edilson Freire Lima
Journal:  World J Biol Chem       Date:  2017-02-26

4.  Benzoic Acid Derivatives with Trypanocidal Activity: Enzymatic Analysis and Molecular Docking Studies toward Trans-Sialidase.

Authors:  Muhammad Kashif; Antonio Moreno-Herrera; Juan Carlos Villalobos-Rocha; Benjamín Nogueda-Torres; Jaime Pérez-Villanueva; Karen Rodríguez-Villar; José Lius Medina-Franco; Peterson de Andrade; Ivone Carvalho; Gildardo Rivera
Journal:  Molecules       Date:  2017-10-30       Impact factor: 4.411

Review 5.  Theft and Reception of Host Cell's Sialic Acid: Dynamics of Trypanosoma Cruzi Trans-sialidases and Mucin-Like Molecules on Chagas' Disease Immunomodulation.

Authors:  Leonardo Marques da Fonseca; Kelli Monteiro da Costa; Victoria de Sousa Chaves; Célio Geraldo Freire-de-Lima; Alexandre Morrot; Lucia Mendonça-Previato; Jose Osvaldo Previato; Leonardo Freire-de-Lima
Journal:  Front Immunol       Date:  2019-02-06       Impact factor: 7.561

6.  Repositioned Drugs for Chagas Disease Unveiled via Structure-Based Drug Repositioning.

Authors:  Melissa F Adasme; Sarah Naomi Bolz; Lauren Adelmann; Sebastian Salentin; V Joachim Haupt; Adriana Moreno-Rodríguez; Benjamín Nogueda-Torres; Verónica Castillo-Campos; Lilián Yepez-Mulia; José A De Fuentes-Vicente; Gildardo Rivera; Michael Schroeder
Journal:  Int J Mol Sci       Date:  2020-11-20       Impact factor: 5.923

7.  Anomeric 1,2,3-triazole-linked sialic acid derivatives show selective inhibition towards a bacterial neuraminidase over a trypanosome trans-sialidase.

Authors:  Peterson de Andrade; Sanaz Ahmadipour; Robert A Field
Journal:  Beilstein J Org Chem       Date:  2022-02-17       Impact factor: 2.883

8.  Insights into the activity and specificity of Trypanosoma cruzi trans-sialidase from molecular dynamics simulations.

Authors:  Felicity L Mitchell; João Neres; Anitha Ramraj; Rajesh K Raju; Ian H Hillier; Mark A Vincent; Richard A Bryce
Journal:  Biochemistry       Date:  2013-05-14       Impact factor: 3.162

9.  Rational design of boron-dipyrromethene (BODIPY) reporter dyes for cucurbit[7]uril.

Authors:  Mohammad A Alnajjar; Jürgen Bartelmeß; Robert Hein; Pichandi Ashokkumar; Mohamed Nilam; Werner M Nau; Knut Rurack; Andreas Hennig
Journal:  Beilstein J Org Chem       Date:  2018-07-30       Impact factor: 2.883
  9 in total

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