| Literature DB >> 17218098 |
Pierre J De Clercq1, Frederik De Buysser, Garrett Minne, Wim Schepens, Freek Vrielynck, Dirk Van Haver, Maurits Vandewalle, Annemieke Verstuyf, Roger Bouillon.
Abstract
During a 20-year collaboration the laboratories of UGent and KU Leuven have developed different series of Vitamin D analogs characterized by structural modifications in the central CD-ring system. Modifications have first involved the introduction of substituents at C11 and the epimerization at C14, and subsequently more drastic changes consisting in both ring deletion and enlargement relative to the natural CD-ring system. Lately, the focus has shifted towards the synthesis of analogs featuring a symmetrical CD-ring core. As an illustration two different series are presented.Entities:
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Year: 2007 PMID： 17218098 DOI： 10.1016/j.jsbmb.2006.12.023
Source DB: PubMed Journal: J Steroid Biochem Mol Biol ISSN： 0960-0760 Impact factor: 4.292