| Literature DB >> 17217303 |
William J Chain1, Andrew G Myers.
Abstract
Amides of pseudoephedrine and ephedrine are shown to undergo highly stereospecific, invertive cyclization to form 4,5-dihydro-3,4-dimethyl-5-phenyl-1,3-oxazolium triflate derivatives in the presence of triflic anhydride-pyridine. 1H NMR spectra of the unpurified reaction products are remarkably clean, with sharp, well-defined peaks, and allow for rapid assessment of the diastereomeric purities of the starting amides. [reaction: see text].Entities:
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Year: 2007 PMID： 17217303 DOI： 10.1021/ol0628762
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005