| Literature DB >> 17217038 |
J S Seeler1, O Bischof, K Nacerddine, A Dejean.
Abstract
SUMO modification (sumoylation) plays important roles in nucleo-cytoplasmic transport, maintenance of sub-nuclear architecture, the regulation of gene expression and in DNA replication, repair and recombination. Here we review recent evidence for SUMO's role in protecting genomic integrity at both the chromosomal and the DNA level. Furthermore, the involvement of sumoylation and of specific SUMO targets in cancer is discussed.Entities:
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Year: 2007 PMID： 17217038 DOI： 10.1007/978-3-540-34594-7_4
Source DB: PubMed Journal: Curr Top Microbiol Immunol ISSN： 0070-217X Impact factor: 4.291