Literature DB >> 17217036

Mouse models of acute promyelocytic leukemia.

S C Kogan1.   

Abstract

Mouse models of acute promyelocytic leukemia have been generated through transgenic, knock-in, retroviral, and xenograft strategies. These models have been used to elucidate mechanisms underlying leukemogenesis. Among the areas investigated are the role of reciprocal fusions; effects of target cells, expression levels, and mouse strains; cooperating events; and restrictive and permissive factors. These models have also been used to gain insight into the effects of the immune system on leukemic cells and the mechanism of response to retinoic acid. Furthermore, preclinical studies utilizing these mice have advanced therapy for myeloid leukemia.

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Year:  2007        PMID： 17217036     DOI： 10.1007/978-3-540-34594-7_2

Source DB:  PubMed          Journal:  Curr Top Microbiol Immunol        ISSN： 0070-217X            Impact factor:   4.291


  14 in total

1.  A protease-resistant PML-RAR{alpha} has increased leukemogenic potential in a murine model of acute promyelocytic leukemia.

Authors:  Geoffrey L Uy; Andrew A Lane; John S Welch; Nicole R Grieselhuber; Jacqueline E Payton; Timothy J Ley
Journal:  Blood       Date:  2010-07-20       Impact factor: 22.113

2.  Treatment-influenced associations of PML-RARα mutations, FLT3 mutations, and additional chromosome abnormalities in relapsed acute promyelocytic leukemia.

Authors:  Robert E Gallagher; Barry K Moser; Janis Racevskis; Xavier Poiré; Clara D Bloomfield; Andrew J Carroll; Rhett P Ketterling; Diane Roulston; Esther Schachter-Tokarz; Da-Cheng Zhou; I-Ming L Chen; Richard Harvey; Greg Koval; Dorie A Sher; James H Feusner; Martin S Tallman; Richard A Larson; Bayard L Powell; Frederick R Appelbaum; Elisabeth Paietta; Cheryl L Willman; Wendy Stock
Journal:  Blood       Date:  2012-06-25       Impact factor: 22.113

3.  The origin and evolution of mutations in acute myeloid leukemia.

Authors:  John S Welch; Timothy J Ley; Daniel C Link; Christopher A Miller; David E Larson; Daniel C Koboldt; Lukas D Wartman; Tamara L Lamprecht; Fulu Liu; Jun Xia; Cyriac Kandoth; Robert S Fulton; Michael D McLellan; David J Dooling; John W Wallis; Ken Chen; Christopher C Harris; Heather K Schmidt; Joelle M Kalicki-Veizer; Charles Lu; Qunyuan Zhang; Ling Lin; Michelle D O'Laughlin; Joshua F McMichael; Kim D Delehaunty; Lucinda A Fulton; Vincent J Magrini; Sean D McGrath; Ryan T Demeter; Tammi L Vickery; Jasreet Hundal; Lisa L Cook; Gary W Swift; Jerry P Reed; Patricia A Alldredge; Todd N Wylie; Jason R Walker; Mark A Watson; Sharon E Heath; William D Shannon; Nobish Varghese; Rakesh Nagarajan; Jacqueline E Payton; Jack D Baty; Shashikant Kulkarni; Jeffery M Klco; Michael H Tomasson; Peter Westervelt; Matthew J Walter; Timothy A Graubert; John F DiPersio; Li Ding; Elaine R Mardis; Richard K Wilson
Journal:  Cell       Date:  2012-07-20       Impact factor: 41.582

4.  PML-RARA can increase hematopoietic self-renewal without causing a myeloproliferative disease in mice.

Authors:  John S Welch; Wenlin Yuan; Timothy J Ley
Journal:  J Clin Invest       Date:  2011-04       Impact factor: 14.808

5.  Rara haploinsufficiency modestly influences the phenotype of acute promyelocytic leukemia in mice.

Authors:  John S Welch; Jeffery M Klco; Nobish Varghese; Rakesh Nagarajan; Timothy J Ley
Journal:  Blood       Date:  2010-12-29       Impact factor: 22.113

6.  Sequencing a mouse acute promyelocytic leukemia genome reveals genetic events relevant for disease progression.

Authors:  Lukas D Wartman; David E Larson; Zhifu Xiang; Li Ding; Ken Chen; Ling Lin; Patrick Cahan; Jeffery M Klco; John S Welch; Cheng Li; Jacqueline E Payton; Geoffrey L Uy; Nobish Varghese; Rhonda E Ries; Mieke Hoock; Daniel C Koboldt; Michael D McLellan; Heather Schmidt; Robert S Fulton; Rachel M Abbott; Lisa Cook; Sean D McGrath; Xian Fan; Adam F Dukes; Tammi Vickery; Joelle Kalicki; Tamara L Lamprecht; Timothy A Graubert; Michael H Tomasson; Elaine R Mardis; Richard K Wilson; Timothy J Ley
Journal:  J Clin Invest       Date:  2011-03-23       Impact factor: 14.808

7.  Finding a needle in a haystack: whole genome sequencing and mutation discovery in murine models.

Authors:  Raajit K Rampal; Ross L Levine
Journal:  J Clin Invest       Date:  2011-03-23       Impact factor: 14.808

8.  PML-RARA-associated cooperating mutations belong to a transcriptional network that is deregulated in myeloid leukemias.

Authors:  C Ronchini; A Brozzi; L Riva; L Luzi; A M Gruszka; G E M Melloni; E Scanziani; G Dharmalingam; M Mutarelli; V Belcastro; S Lavorgna; V Rossi; O Spinelli; A Biondi; A Rambaldi; F Lo-Coco; D di Bernardo; P G Pelicci
Journal:  Leukemia       Date:  2016-12-27       Impact factor: 11.528

9.  PML-RARA requires DNA methyltransferase 3A to initiate acute promyelocytic leukemia.

Authors:  Christopher B Cole; Angela M Verdoni; Shamika Ketkar; Elizabeth R Leight; David A Russler-Germain; Tamara L Lamprecht; Ryan T Demeter; Vincent Magrini; Timothy J Ley
Journal:  J Clin Invest       Date:  2015-11-23       Impact factor: 14.808

10.  Extrinsic apoptosis is impeded by direct binding of the APL fusion protein NPM-RAR to TRADD.

Authors:  Anuja Chattopadhyay; Brian L Hood; Thomas P Conrads; Robert L Redner
Journal:  Mol Cancer Res       Date:  2014-07-17       Impact factor: 5.852
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