Inflammatory response to fungal keratitis.

Ocular fungal infections occur worldwide and are important contributors to vision loss. While many aspects of the microbe and host interaction involved in fungal keratitis remain undefined, two aspects known to affect susceptibility are disruption of the epithelial barrier and immunosuppression of the host. Our recent pathogenesis studies using an experimental murine model have provided insight into the influence of these factors on keratomycosis. Increased susceptibility was associated with greater neutrophilic infiltration, greater fungal invasion of the corneal stroma, up-regulation of matrix metalloproteinase-9, and morphogenic switching from yeast to hyphae. Understanding the pathogenic events of fungal keratitis will identify potential targets for therapeutic intervention of these sight-threatening infections.