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Literature DB >> 1721492

The N terminal region of human tau is present in Alzheimer's disease protein A68 and is incorporated into paired helical filaments.

A Crowe¹, H Ksiezak-Reding, W K Liu, D W Dickson, S H Yen.

Abstract

Antibody (Ab) E-1 was raised to the amino terminus (19 to 33 amino acid residues) of human tau. It recognized Alzheimer's disease proteins A68 (MW 60, 64, 68 kd), labeled paired helical filaments, and had no reactivity with tau from rat, mouse, and bovine brains. The results indicate that the N terminus of tau is incorporated in A68 proteins and paired helical filaments and that human tau proteins contain species-specific amino acid sequences.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 1991 PMID： 1721492 PMCID： PMC1886469

Source DB: PubMed Journal: Am J Pathol ISSN： 0002-9440 Impact factor: 4.307

25 in total

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