BACKGROUND: Spleen tyrosine kinase (Syk) kinase has recently been considered as a tumor suppressor gene in breast cancer. MATERIALS AND METHODS: Syk expression in patients with invasive breast cancer was immunohistochemically assessed. RESULTS: Decreased expression was found in 26% of the specimens examined. In cases with vascular invasion, expression of Syk was lost in the intravascular emboli. A significant relationship between increased proliferation levels (as estimated by the proliferative index, Ki67) and decreased Syk expression (p <0.05) was found. CONCLUSION: Our data suggest that Syk protein expression inversely correlates with the proliferation and invasive capacity of breast cancer.
BACKGROUND:Spleen tyrosine kinase (Syk) kinase has recently been considered as a tumor suppressor gene in breast cancer. MATERIALS AND METHODS:Syk expression in patients with invasive breast cancer was immunohistochemically assessed. RESULTS: Decreased expression was found in 26% of the specimens examined. In cases with vascular invasion, expression of Syk was lost in the intravascular emboli. A significant relationship between increased proliferation levels (as estimated by the proliferative index, Ki67) and decreased Syk expression (p <0.05) was found. CONCLUSION: Our data suggest that Syk protein expression inversely correlates with the proliferation and invasive capacity of breast cancer.
Authors: Montiago X LaBute; Xiaohua Zhang; Jason Lenderman; Brian J Bennion; Sergio E Wong; Felice C Lightstone Journal: PLoS One Date: 2014-09-05 Impact factor: 3.240
Authors: Tamar Zahavi; Amir Sonnenblick; Asher Y Salmon; Mali Salmon-Divon; Yael Shimshon; Luna Kadouri; Tamar Peretz Journal: Cancer Manag Res Date: 2018-03-26 Impact factor: 3.989