Literature DB >> 17213642

Structure-activity relationship study of the bacterial actin-like protein MreB inhibitors: effects of substitution of benzyl group in S-benzylisothiourea.

Noritaka Iwai1, Takuya Fujii, Hirokatsu Nagura, Masaaki Wachi, Tomoya Kitazume.   

Abstract

We comprehensively investigated the effects of substitution of the benzyl group in S-benzylisothiourea derivatives on antibacterial activity, because we found previously that some substitutions enhanced it. A 2,4-Cl2-derivative was found to be the most effective compound, it was stronger than the original one in Gram-negative rod shaped-bacteria such as Escherichia coli and Salmonella typhimurium.

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Year:  2007        PMID： 17213642     DOI： 10.1271/bbb.60443

Source DB:  PubMed          Journal:  Biosci Biotechnol Biochem        ISSN： 0916-8451            Impact factor:   2.043


  9 in total

1.  MreB drives de novo rod morphogenesis in Caulobacter crescentus via remodeling of the cell wall.

Authors:  Constantin N Takacs; Sebastian Poggio; Godefroid Charbon; Mathieu Pucheault; Waldemar Vollmer; Christine Jacobs-Wagner
Journal:  J Bacteriol       Date:  2009-12-18       Impact factor: 3.490

2.  Pathway-Directed Screen for Inhibitors of the Bacterial Cell Elongation Machinery.

Authors:  Jackson A Buss; Vadim Baidin; Michael A Welsh; Josué Flores-Kim; Hongbaek Cho; B McKay Wood; Tsuyoshi Uehara; Suzanne Walker; Daniel Kahne; Thomas G Bernhardt
Journal:  Antimicrob Agents Chemother       Date:  2018-12-21       Impact factor: 5.191

3.  Route of intrabacterial nanotransportation system for CagA in Helicobacter pylori.

Authors:  Hong Wu; Noritaka Iwai; Takashi Nakano; Yukimasa Ooi; Sonoko Ishihara; Kouichi Sano
Journal:  Med Mol Morphol       Date:  2015-02-24       Impact factor: 2.309

4.  A22 disrupts the bacterial actin cytoskeleton by directly binding and inducing a low-affinity state in MreB.

Authors:  G J Bean; S T Flickinger; W M Westler; M E McCully; D Sept; D B Weibel; K J Amann
Journal:  Biochemistry       Date:  2009-06-09       Impact factor: 3.162

5.  A Novel indole compound that inhibits Pseudomonas aeruginosa growth by targeting MreB is a substrate for MexAB-OprM.

Authors:  Gregory T Robertson; Timothy B Doyle; Qun Du; Leonard Duncan; Khisimuzi E Mdluli; A Simon Lynch
Journal:  J Bacteriol       Date:  2007-07-20       Impact factor: 3.490

6.  Functional analysis of the cytoskeleton protein MreB from Chlamydophila pneumoniae.

Authors:  Ahmed Gaballah; Anna Kloeckner; Christian Otten; Hans-Georg Sahl; Beate Henrichfreise
Journal:  PLoS One       Date:  2011-10-05       Impact factor: 3.240

7.  Antimicrobial activity of allylic thiocyanates derived from the Morita-Baylis-Hillman reaction.

Authors:  Marcus Mandolesi Sá; Misael Ferreira; Emerson Silva Lima; Ivanildes dos Santos; Patrícia Puccinelli Orlandi; Luciano Fernandes
Journal:  Braz J Microbiol       Date:  2014-10-09       Impact factor: 2.476

8.  Targeting the Bacterial Cytoskeleton of the Burkholderia cepacia Complex for Antimicrobial Development: A Cautionary Tale.

Authors:  Sonya C Carnell; John D Perry; Lee Borthwick; Daniela Vollmer; Jacob Biboy; Marcella Facchini; Alessandra Bragonzi; Alba Silipo; Annette C Vergunst; Waldemar Vollmer; Anjam C M Khan; Anthony De Soyza
Journal:  Int J Mol Sci       Date:  2018-05-30       Impact factor: 5.923

9.  A CRISPR interference platform for selective downregulation of gene expression in Borrelia burgdorferi.

Authors:  Constantin N Takacs; Molly Scott; Yunjie Chang; Zachary A Kloos; Irnov Irnov; Patricia A Rosa; Jun Liu; Christine Jacobs-Wagner
Journal:  Appl Environ Microbiol       Date:  2020-11-30       Impact factor: 4.792
  9 in total

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