| Literature DB >> 17213025 |
Fábio Morato de Oliveira1, Luiz Gonzaga Tone, Belinda Pinto Simões, Roberto Passetto Falcão, María Sol Brassesco, Elza Tiemi Sakamoto-Hojo, Guilherme Augusto Silva dos Santos, André Fiorin Marinato, Rafael Henriques Jácomo, Eduardo Magalhães Rego.
Abstract
We report a case of acute myeloid leukemia (AML) subtype M2, with t(5;11)(q35;q13), in a 30-year-old man. Conventional cytogenetic, spectral karyotyping, and fluorescence in situ hybridization (FISH) studies on bone marrow sample obtained at diagnosis revealed an abnormal karyotype in all cells examined. FISH analysis demonstrated absence of translocations in the region of the cyclin D1 gene and real-time quantitative reverse transcriptase-polymerase chain reaction revealed normal expression of this gene. Similar to the 11q23 region, 11q13 changes can be found in both myeloid and lymphoid neoplasias with different chromosomes serving as donors in translocations.Entities:
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Year: 2007 PMID： 17213025 DOI： 10.1016/j.cancergencyto.2006.09.004
Source DB: PubMed Journal: Cancer Genet Cytogenet ISSN： 0165-4608