BACKGROUND: Neurosurgical procedures are carried out routinely in health institutions across the world. A key issue to be considered during neurosurgical interventions is that there is always an element of inevitable brain injury that results from the procedure itself because of the unique nature of the nervous system. Brain tissue at the periphery of the operative site is at risk of injury by various means, including incisions and direct trauma, electrocautery, hemorrhage, and retractor stretch. METHODS/ RESULTS: In the present review, we will elaborate upon this surgically induced brain injury and also present a novel animal model to study it. In addition, we will summarize preliminary results obtained by pretreatment with PP1, an Src tyrosine kinase inhibitor reported to have neuroprotective properties in in vivo experimental studies. Any form of pretreatment to limit the damage to the susceptible functional brain tissue during neurosurgical procedures may have a significant impact on patient recovery. CONCLUSION: This brief review is intended to raise the question of 'neuroprotection against surgically induced brain injury' in the neurosurgical scientific community and stimulate discussions.
BACKGROUND: Neurosurgical procedures are carried out routinely in health institutions across the world. A key issue to be considered during neurosurgical interventions is that there is always an element of inevitable brain injury that results from the procedure itself because of the unique nature of the nervous system. Brain tissue at the periphery of the operative site is at risk of injury by various means, including incisions and direct trauma, electrocautery, hemorrhage, and retractor stretch. METHODS/ RESULTS: In the present review, we will elaborate upon this surgically induced brain injury and also present a novel animal model to study it. In addition, we will summarize preliminary results obtained by pretreatment with PP1, an Src tyrosine kinase inhibitor reported to have neuroprotective properties in in vivo experimental studies. Any form of pretreatment to limit the damage to the susceptible functional brain tissue during neurosurgical procedures may have a significant impact on patient recovery. CONCLUSION: This brief review is intended to raise the question of 'neuroprotection against surgically induced brain injury' in the neurosurgical scientific community and stimulate discussions.
Authors: Robert E Ayer; Nazanin Jafarian; Wanqiu Chen; Richard L Applegate; Austin R T Colohan; John H Zhang Journal: J Neurosurg Date: 2011-10-21 Impact factor: 5.115
Authors: Steve Lee; Vikram Jadhav; Robert E Ayer; Hugo Rojas; Amy Hyong; Tim Lekic; Jiping Tang; John H Zhang Journal: J Pineal Res Date: 2008-06-18 Impact factor: 13.007
Authors: Anthony J Baucum; Nidhi Jalan-Sakrikar; Yuxia Jiao; Richard M Gustin; Leigh C Carmody; David L Tabb; Amy-Joan L Ham; Roger J Colbran Journal: Mol Cell Proteomics Date: 2010-02-02 Impact factor: 5.911
Authors: Nikan H Khatibi; Vikram Jadhav; Mehdi Saidi; Wanqiu Chen; Robert Martin; Gary Stier; Jiping Tang; John H Zhang Journal: Acta Neurochir Suppl Date: 2011
Authors: Nikan H Khatibi; Vikram Jadhav; Brenden Matus; Nancy Fathali; Robert Martin; Richard Applegate; Jiping Tang; John H Zhang Journal: Acta Neurochir Suppl Date: 2011