Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Roles of the LHX3 and LHX4 LIM-homeodomain factors in pituitary development.

Literature DB >> 17210222

Roles of the LHX3 and LHX4 LIM-homeodomain factors in pituitary development.

Rachel D Mullen¹, Stephanie C Colvin, Chad S Hunter, Jesse J Savage, Emily C Walvoord, Amrit P S Bhangoo, Svetlana Ten, Johannes Weigel, Roland W Pfäffle, Simon J Rhodes.

Abstract

The LHX3 and LHX4 LIM-homeodomain transcription factors play essential roles in pituitary gland and nervous system development. Mutations in the genes encoding these regulatory proteins are associated with combined hormone deficiency diseases in humans and animal models. Patients with these diseases have complex syndromes involving short stature, and reproductive and metabolic disorders. Analyses of the features of these diseases and the biochemical properties of the LHX3 and LHX4 proteins will facilitate a better understanding of the molecular pathways that regulate the development of the specialized hormone-secreting cells of the mammalian anterior pituitary gland.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 2007 PMID： 17210222 PMCID： PMC1853274 DOI： 10.1016/j.mce.2006.12.019

Source DB: PubMed Journal: Mol Cell Endocrinol ISSN： 0303-7207 Impact factor: 4.102

44 in total

1. LIM factor Lhx3 contributes to the specification of motor neuron and interneuron identity through cell-type-specific protein-protein interactions.

Authors: Joshua P Thaler; Soo-Kyung Lee; Linda W Jurata; Gordon N Gill; Samuel L Pfaff
Journal: Cell Date: 2002-07-26 Impact factor: 41.582

2. P-Lim, a LIM homeodomain factor, is expressed during pituitary organ and cell commitment and synergizes with Pit-1.

Authors: I Bach; S J Rhodes; R V Pearse; T Heinzel; B Gloss; K M Scully; P E Sawchenko; M G Rosenfeld
Journal: Proc Natl Acad Sci U S A Date: 1995-03-28 Impact factor: 11.205

3. Regulation of the follicle-stimulating hormone beta gene by the LHX3 LIM-homeodomain transcription factor.

Authors: Brooke E West; Gretchen E Parker; Jesse J Savage; Parinda Kiratipranon; Katherine S Toomey; Lisa R Beach; Stephanie C Colvin; Kyle W Sloop; Simon J Rhodes
Journal: Endocrinology Date: 2004-07-22 Impact factor: 4.736

4. Aberrant expression of the LHX4 LIM-homeobox gene caused by t(1;14)(q25;q32) in chronic myelogenous leukemia in biphenotypic blast crisis.

Authors: Mitsuko Yamaguchi; Koh Yamamoto; Osamu Miura
Journal: Genes Chromosomes Cancer Date: 2003-11 Impact factor: 5.006

5. The mouse homeoprotein mLIM-3 is expressed early in cells derived from the neuroepithelium and persists in adult pituitary.

Authors: N G Seidah; J C Barale; M Marcinkiewicz; M G Mattei; R Day; M Chrétien
Journal: DNA Cell Biol Date: 1994-12 Impact factor: 3.311

6. A novel chromosomal translocation t(1;14)(q25;q32) in pre-B acute lymphoblastic leukemia involves the LIM homeodomain protein gene, Lhx4.

Authors: Norihiko Kawamata; Sakura Sakajiri; Kei-Ji Sugimoto; Yasushi Isobe; Hirofumi Kobayashi; Kazuo Oshimi
Journal: Oncogene Date: 2002-07-25 Impact factor: 9.867

7. Genomic structure and chromosomal localization of the mouse LIM/homeobox gene Lhx3.

Authors: A B Zhadanov; N G Copeland; D J Gilbert; N A Jenkins; H Westphal
Journal: Genomics Date: 1995-05-01 Impact factor: 5.736

8. Expression pattern of the murine LIM class homeobox gene Lhx3 in subsets of neural and neuroendocrine tissues.

Authors: A B Zhadanov; S Bertuzzi; M Taira; I B Dawid; H Westphal
Journal: Dev Dyn Date: 1995-04 Impact factor: 3.780

9. Gsh-4 encodes a LIM-type homeodomain, is expressed in the developing central nervous system and is required for early postnatal survival.

Authors: H Li; D P Witte; W W Branford; B J Aronow; M Weinstein; S Kaur; S Wert; G Singh; C M Schreiner; J A Whitsett
Journal: EMBO J Date: 1994-06-15 Impact factor: 11.598

10. Lhx4 and Prop1 are required for cell survival and expansion of the pituitary primordia.

Authors: Lori T Raetzman; Robert Ward; Sally A Camper
Journal: Development Date: 2002-09 Impact factor: 6.868

22 in total

1. Analysis of protocadherin alpha gene enhancer polymorphism in bipolar disorder and schizophrenia.

Authors: Erika Pedrosa; Radu Stefanescu; Benjamin Margolis; Oriana Petruolo; Yungtai Lo; Karen Nolan; Tomas Novak; Pavla Stopkova; Herbert M Lachman
Journal: Schizophr Res Date: 2008-05-27 Impact factor: 4.939

Review 2. Molecular mechanisms of pituitary organogenesis: In search of novel regulatory genes.

Authors: S W Davis; F Castinetti; L R Carvalho; B S Ellsworth; M A Potok; R H Lyons; M L Brinkmeier; L T Raetzman; P Carninci; A H Mortensen; Y Hayashizaki; I J P Arnhold; B B Mendonça; T Brue; S A Camper
Journal: Mol Cell Endocrinol Date: 2009-12-16 Impact factor: 4.102

10. GATA2-induced silencing and LIM-homeodomain protein-induced activation are mediated by a bi-functional response element in the rat GnRH receptor gene.

Authors: Anne-Laure Schang; Anne Granger; Bruno Quérat; Christian Bleux; Joëlle Cohen-Tannoudji; Jean-Noël Laverrière
Journal: Mol Endocrinol Date: 2012-12-04

Roles of the LHX3 and LHX4 LIM-homeodomain factors in pituitary development.

1. LIM factor Lhx3 contributes to the specification of motor neuron and interneuron identity through cell-type-specific protein-protein interactions.

2. P-Lim, a LIM homeodomain factor, is expressed during pituitary organ and cell commitment and synergizes with Pit-1.

3. Regulation of the follicle-stimulating hormone beta gene by the LHX3 LIM-homeodomain transcription factor.

4. Aberrant expression of the LHX4 LIM-homeobox gene caused by t(1;14)(q25;q32) in chronic myelogenous leukemia in biphenotypic blast crisis.

5. The mouse homeoprotein mLIM-3 is expressed early in cells derived from the neuroepithelium and persists in adult pituitary.

6. A novel chromosomal translocation t(1;14)(q25;q32) in pre-B acute lymphoblastic leukemia involves the LIM homeodomain protein gene, Lhx4.

7. Genomic structure and chromosomal localization of the mouse LIM/homeobox gene Lhx3.

8. Expression pattern of the murine LIM class homeobox gene Lhx3 in subsets of neural and neuroendocrine tissues.

9. Gsh-4 encodes a LIM-type homeodomain, is expressed in the developing central nervous system and is required for early postnatal survival.

10. Lhx4 and Prop1 are required for cell survival and expansion of the pituitary primordia.

1. Analysis of protocadherin alpha gene enhancer polymorphism in bipolar disorder and schizophrenia.

Review 2. Molecular mechanisms of pituitary organogenesis: In search of novel regulatory genes.

3. Genome-wide profiling of in vivo LPS-responsive genes in splenic myeloid cells.

4. ISL1 Is Necessary for Maximal Thyrotrope Response to Hypothyroidism.

Review 5. An emerging link between LIM domain proteins and nuclear receptors.

6. Three novel single-nucleotide polymorphisms of the bovine LHX3 gene.

7. A role of the LIM-homeobox gene Lhx2 in the regulation of pituitary development.

8. A coding SNP of LHX4 gene is associated with body weight and body length in bovine.

9. Congenital adenohypophyseal hypoplasia associated with secondary hypothyroidism in a 2-week-old Portuguese water dog.

10. GATA2-induced silencing and LIM-homeodomain protein-induced activation are mediated by a bi-functional response element in the rat GnRH receptor gene.