Literature DB >> 1721014

Anti-human thyroid peroxidase and anti-human thyroglobulin antibodies present no cross-reactivity on recombinant peptides.

M Henry1, E Zanelli, Y Malthiery.   

Abstract

Thyroglobulin (Tg) and thyroid peroxidase (TPO) are two antigens largely recognized by the sera from patients with autoimmune thyroid disease (AITD). Recently, the complete mapping of both antigens was established with rabbit polyclonal antibodies by the use of recombinant proteins expressed in prokaryotic vector. Several investigators have argued for the existence of a cross-reactivity of some hetero- and autologous antibodies versus these two proteins. In the present study, using rabbit polyclonal antibody, mouse polyclonal antibody and autoimmune antibody (aAb), we observed no common epitope on human Tg (hTg) and human TPO (hTPO).

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Year:  1991        PMID： 1721014      PMCID： PMC1554185          DOI： 10.1111/j.1365-2249.1991.tb02956.x

Source DB:  PubMed          Journal:  Clin Exp Immunol        ISSN： 0009-9104            Impact factor:   4.330


  23 in total

1.  Anti-thyroid peroxidase antibody in patients with autoimmune thyroid disease: possible identity with anti-microsomal antibody.

Authors:  L Portmann; N Hamada; G Heinrich; L J DeGroot
Journal:  J Clin Endocrinol Metab       Date:  1985-11       Impact factor: 5.958

2.  Thyroglobulin and thyroid peroxidase share common epitopes recognized by autoantibodies in patients with chronic autoimmune thyroiditis.

Authors:  Y Kohno; N Naito; Y Hiyama; N Shimojo; N Suzuki; O Tarutani; H Niimi; H Nakajima; T Hosoya
Journal:  J Clin Endocrinol Metab       Date:  1988-11       Impact factor: 5.958

3.  Cleavage of structural proteins during the assembly of the head of bacteriophage T4.

Authors:  U K Laemmli
Journal:  Nature       Date:  1970-08-15       Impact factor: 49.962

4.  Towards an antigenic map of human thyroglobulin: identification of ten epitope-bearing sequences within the primary structure of thyroglobulin.

Authors:  Q Dong; M Ludgate; G Vassart
Journal:  J Endocrinol       Date:  1989-07       Impact factor: 4.286

5.  Human thyroid peroxidase: complete cDNA and protein sequence, chromosome mapping, and identification of two alternately spliced mRNAs.

Authors:  S Kimura; T Kotani; O W McBride; K Umeki; K Hirai; T Nakayama; S Ohtaki
Journal:  Proc Natl Acad Sci U S A       Date:  1987-08       Impact factor: 11.205

6.  Highly sensitive assays of autoantibodies to thyroglobulin and to thyroid peroxidase.

Authors:  K Beever; J Bradbury; D Phillips; S M McLachlan; C Pegg; A Goral; W Overbeck; G Feifel; B R Smith
Journal:  Clin Chem       Date:  1989-09       Impact factor: 8.327

7.  Detection of autoantibodies to thyroid peroxidase in autoimmune thyroid diseases by micro-ELISA and immunoblotting.

Authors:  T Kotani; K Umeki; S Matsunaga; E Kato; S Ohtaki
Journal:  J Clin Endocrinol Metab       Date:  1986-05       Impact factor: 5.958

8.  Purification of the human thyroid peroxidase and its identification as the microsomal antigen involved in autoimmune thyroid diseases.

Authors:  B Czarnocka; J Ruf; M Ferrand; P Carayon; S Lissitzky
Journal:  FEBS Lett       Date:  1985-10-07       Impact factor: 4.124

9.  Structural features of the autoantigens involved in thyroid autoimmune disease: the thyroid microsomal/microvillar antigen.

Authors:  J P Banga; G Pryce; L Hammond; I M Roitt
Journal:  Mol Immunol       Date:  1985-06       Impact factor: 4.407

10.  Evidence for a potential common T-cell epitope between human thyroid peroxidase and human thyroglobulin with implications for the pathogenesis of autoimmune thyroid disease.

Authors:  S M McLachlan; B Rapoport
Journal:  Autoimmunity       Date:  1989       Impact factor: 2.815
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  2 in total

1.  Significance of thyroglobulin antibodies cross-reactive with thyroperoxidase (TGPO antibodies) in individual patients and immunized mice.

Authors:  J Ruf; M Ferrand; J M Durand-Gorde; C De Micco; P Carayon
Journal:  Clin Exp Immunol       Date:  1993-04       Impact factor: 4.330

2.  Antibodies cross-reacting with thyroglobulin and thyroid peroxidase are induced by immunization of rabbits with an immunogenic thyroglobulin 20mer peptide.

Authors:  A Thrasyvoulides; P Lymberi
Journal:  Clin Exp Immunol       Date:  2004-12       Impact factor: 4.330
  2 in total

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