BACKGROUND: The relation between respiratory illnesses in early life and the development of asthma and atopy in childhood is incompletely understood. OBJECTIVE: We sought to examine the relationship between respiratory illnesses in early life and atopic diseases at school age. METHODS: We performed a prospective birth cohort study of the relationship between respiratory illnesses in the first year of life and asthma, atopy (sensitization to >or=1 allergen), and allergic rhinitis at school age in 440 children with a parental history of atopy. Logistic regression was used to examine the relationship between respiratory illnesses and asthma, atopy, and allergic rhinitis. The relationship between respiratory illnesses in early life and repeated measures of wheezing between the ages of 1 and 7 years was investigated by using a proportional hazards models. RESULTS: Physician-diagnosed croup (adjusted odds ratio [OR], 0.30; 95% CI, 0.12-0.72) and having 2 or more physician-diagnosed ear infections (adjusted OR, 0.58; 95% CI, 0.35-0.98) in the first year of life were inversely associated with atopy at school age. Physician-diagnosed bronchiolitis before age 1 year was significantly associated with asthma at age 7 years (adjusted OR, 2.77; 95% CI, 1.23-6.22). Recurrent nasal catarrh (>or=3 episodes of a runny nose) in the first year of life was associated with allergic rhinitis at age 7 years (adjusted OR, 2.99; 95% CI, 1.03-8.67). CONCLUSION: The relationship between early-life respiratory illnesses and asthma and atopy is complex and likely dependent on the type of infection and immune response it initiates. CLINICAL IMPLICATIONS: Certain respiratory illnesses in early life modify the risk of atopy and asthma at school age.
BACKGROUND: The relation between respiratory illnesses in early life and the development of asthma and atopy in childhood is incompletely understood. OBJECTIVE: We sought to examine the relationship between respiratory illnesses in early life and atopic diseases at school age. METHODS: We performed a prospective birth cohort study of the relationship between respiratory illnesses in the first year of life and asthma, atopy (sensitization to >or=1 allergen), and allergic rhinitis at school age in 440 children with a parental history of atopy. Logistic regression was used to examine the relationship between respiratory illnesses and asthma, atopy, and allergic rhinitis. The relationship between respiratory illnesses in early life and repeated measures of wheezing between the ages of 1 and 7 years was investigated by using a proportional hazards models. RESULTS: Physician-diagnosed croup (adjusted odds ratio [OR], 0.30; 95% CI, 0.12-0.72) and having 2 or more physician-diagnosed ear infections (adjusted OR, 0.58; 95% CI, 0.35-0.98) in the first year of life were inversely associated with atopy at school age. Physician-diagnosed bronchiolitis before age 1 year was significantly associated with asthma at age 7 years (adjusted OR, 2.77; 95% CI, 1.23-6.22). Recurrent nasal catarrh (>or=3 episodes of a runny nose) in the first year of life was associated with allergic rhinitis at age 7 years (adjusted OR, 2.99; 95% CI, 1.03-8.67). CONCLUSION: The relationship between early-life respiratory illnesses and asthma and atopy is complex and likely dependent on the type of infection and immune response it initiates. CLINICAL IMPLICATIONS: Certain respiratory illnesses in early life modify the risk of atopy and asthma at school age.
Authors: Augusto A Litonjua; Nancy E Lange; Vincent J Carey; Stacey Brown; Nancy Laranjo; Benjamin J Harshfield; George T O'Connor; Megan Sandel; Robert C Strunk; Leonard B Bacharier; Robert S Zeiger; Michael Schatz; Bruce W Hollis; Scott T Weiss Journal: Contemp Clin Trials Date: 2014-03-12 Impact factor: 2.226
Authors: Christian Rosas-Salazar; Tebeb Gebretsadik; Kecia N Carroll; Sara Reiss; Nancy Wickersham; Emma K Larkin; Kristina M James; E Kathryn Miller; Larry J Anderson; Tina V Hartert Journal: Pediatr Allergy Immunol Pulmonol Date: 2015-09-01 Impact factor: 1.349
Authors: Roberta L Keller; Rui Feng; Sara B DeMauro; Thomas Ferkol; William Hardie; Elizabeth E Rogers; Timothy P Stevens; Judith A Voynow; Scarlett L Bellamy; Pamela A Shaw; Paul E Moore Journal: J Pediatr Date: 2017-05-17 Impact factor: 4.406
Authors: Haejin Kim; Linda Levin; Grace K LeMasters; Manuel Villareal; Sherry Evans; James E Lockey; Gurjit K Khurana Hershey; David I Bernstein Journal: Ann Allergy Asthma Immunol Date: 2012-02-28 Impact factor: 6.347
Authors: B Behbod; J E Sordillo; E B Hoffman; S Datta; T E Webb; D L Kwan; J A Kamel; M L Muilenberg; J A Scott; G L Chew; T A E Platts-Mills; J Schwartz; B Coull; H Burge; D R Gold Journal: Clin Exp Allergy Date: 2015-01 Impact factor: 5.018