Literature DB >> 17208449

Gonadotropin-releasing hormone neuron remodeling: causal for puberty onset?

Tony M Plant1.   

Abstract

The concept that regulation of neurosecretory function is coupled to structural remodeling of the underlying neuronal network is not new but the developmental changes in the hypothalamic gonadotropin-releasing hormone system of the postnatal male mouse recently reported by Herbison's group are unexpectedly marked, involving both the soma and dendrite. Does this plasticity underlie the pubertal increase in pulsatile gonadotropin-releasing hormone release that takes the animal into adulthood?

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Year:  2007        PMID: 17208449     DOI: 10.1016/j.tem.2006.12.004

Source DB:  PubMed          Journal:  Trends Endocrinol Metab        ISSN: 1043-2760            Impact factor:   12.015


  2 in total

1.  Spatially selective, testosterone-independent remodeling of dendrites in gonadotropin-releasing hormone (GnRH) neurons prepubertally in male rats.

Authors:  Natividad Ybarra; Peter J Hemond; Michael P O'Boyle; Kelly J Suter
Journal:  Endocrinology       Date:  2011-02-22       Impact factor: 4.736

2.  Effect of transient hypothyroidism during infancy on the postnatal ontogeny of luteinising hormone release in the agonadal male rhesus monkey (Macaca mulatta): implications for the timing of puberty in higher primates.

Authors:  T M Plant; S Ramaswamy; G K Bhat; C D Stah; C R Pohl; D R Mann
Journal:  J Neuroendocrinol       Date:  2008-07-30       Impact factor: 3.627

  2 in total

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