Literature DB >> 17208032

Shiga toxin binding in normal and inflamed human intestinal mucosa.

Stephanie Schüller1, Robert Heuschkel, Franco Torrente, James B Kaper, Alan D Phillips.   

Abstract

Shiga toxins are associated with haemolytic uraemic syndrome but human intestinal epithelium does not express the Gb3 receptor. We describe Gb3 expression and Shiga toxin binding in histologically normal intestine and demonstrate that the pattern is unaltered in inflammatory disease states. Gb3 expression and Shiga toxin binding were identified in Paneth cells in both normal and inflamed mucosae.

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Year:  2006        PMID： 17208032     DOI： 10.1016/j.micinf.2006.10.005

Source DB:  PubMed          Journal:  Microbes Infect        ISSN： 1286-4579            Impact factor:   2.700


  28 in total

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