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Literature DB >> 17207467

TRB3 modulates C2C12 differentiation by interfering with Akt activation.

Abstract

TRB3 is a member of TRB protein family characterized by containing a variant kinase domain without enzymatic activity. Interacting with Ser/Thr protein kinases Akt, TRB3 impairs Akt activation induced by growth factors and insulin. In this study we have examined the potential role of TRB3 in muscle differentiation. Our data indicated that the expression of TRB3 is downregulated during C2C12 cells undergoing muscle differentiation and that overexpression of TRB3 inhibits Akt activation during differentiation. Correspondingly, overexpression of TRB3 inhibits, while knockdown TRB3 enhances C2C12 differentiation. Thus, our studies indicated that TRB3 plays a critical role in muscle differentiation.

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Year: 2006 PMID： 17207467 DOI： 10.1016/j.bbrc.2006.12.161

Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.575

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Cited

27 in total

1. Trb3 regulates LR axis formation in zebrafish embryos.

Authors: Mrudhula Anuppalle; Sateesh Maddirevula; Tae-Lin Huh; Myungchull Rhee
Journal: Mol Cells Date: 2013-11-27 Impact factor: 5.034

2. ClipR-59 interacts with Elmo2 and modulates myoblast fusion.

Authors: Yingmin Sun; Wenying Ren; Jean-François Côté; Philip W Hinds; Xiaoxiang Hu; Keyong Du
Journal: J Biol Chem Date: 2015-01-08 Impact factor: 5.157

3. Mixed lineage kinase-3 stabilizes and functionally cooperates with TRIBBLES-3 to compromise mitochondrial integrity in cytokine-induced death of pancreatic beta cells.

Authors: Rohan K Humphrey; Christina J Newcomb; Shu-Mei A Yu; Ergeng Hao; Doris Yu; Stan Krajewski; Keyong Du; Ulupi S Jhala
Journal: J Biol Chem Date: 2010-04-26 Impact factor: 5.157

4. Fatty acids differentially regulate insulin resistance through endoplasm reticulum stress-mediated induction of tribbles homologue 3: a potential link between dietary fat composition and the pathophysiological outcomes of obesity.

Authors: T Geng; W Hu; M H Broadwater; J M Snider; J Bielawski; S B Russo; J H Schwacke; J Ross; L A Cowart
Journal: Diabetologia Date: 2013-07-03 Impact factor: 10.122

5. A novel regulatory mechanism of the bone morphogenetic protein (BMP) signaling pathway involving the carboxyl-terminal tail domain of BMP type II receptor.

Authors: Mun Chun Chan; Peter H Nguyen; Brandi N Davis; Nobumichi Ohoka; Hidetoshi Hayashi; Keyong Du; Giorgio Lagna; Akiko Hata
Journal: Mol Cell Biol Date: 2007-06-18 Impact factor: 4.272

TRB3 modulates C2C12 differentiation by interfering with Akt activation.

1. Trb3 regulates LR axis formation in zebrafish embryos.

2. ClipR-59 interacts with Elmo2 and modulates myoblast fusion.

3. Mixed lineage kinase-3 stabilizes and functionally cooperates with TRIBBLES-3 to compromise mitochondrial integrity in cytokine-induced death of pancreatic beta cells.

4. Fatty acids differentially regulate insulin resistance through endoplasm reticulum stress-mediated induction of tribbles homologue 3: a potential link between dietary fat composition and the pathophysiological outcomes of obesity.

5. A novel regulatory mechanism of the bone morphogenetic protein (BMP) signaling pathway involving the carboxyl-terminal tail domain of BMP type II receptor.

6. COP1 functions as a FoxO1 ubiquitin E3 ligase to regulate FoxO1-mediated gene expression.

7. Overexpression of TRB3 in muscle alters muscle fiber type and improves exercise capacity in mice.

8. Tribbles 3 inhibits brown adipocyte differentiation and function by suppressing insulin signaling.

9. Loss of TRB3 alters dynamics of MLK3-JNK signaling and inhibits cytokine-activated pancreatic beta cell death.

10. Abnormal expression of TRIB3 in colorectal cancer: a novel marker for prognosis.