OBJECTIVE: Adipocyte-derived resistin is a circulating protein implicated in insulin resistance, but the role of human resistin is uncertain because it is produced largely by macrophages. The aim of this study was to analyze serum resistin concentrations in rheumatoid arthritis (RA) patients to determine the role of resistin in human inflammatory diseases. MATERIALS AND METHODS: Resistin concentrations were assessed by ELISA in serum samples from 42 patients with RA. Serum samples from 38 healthy subjects acted as controls. We also evaluated the circulating levels of tumor necrosis factor- alpha (TNF-alpha) and disease activity markers in RA patients. RESULTS: In RA patients, serum resistin levels were significantly higher than those in healthy subjects. Serum resistin levels in RA patients were correlated with the RA disease activity markers, CRP and ESR. Furthermore, resistin levels in RA patients were significantly correlated with circulating levels of TNF-alpha. CONCLUSION: Serum resistin levels were significantly increased in RA patients and correlated with inflammatory markers and TNF-alpha, suggesting that resistin may play a role in the rheumatoid inflammatory process.
OBJECTIVE: Adipocyte-derived resistin is a circulating protein implicated in insulin resistance, but the role of humanresistin is uncertain because it is produced largely by macrophages. The aim of this study was to analyze serum resistin concentrations in rheumatoid arthritis (RA) patients to determine the role of resistin in human inflammatory diseases. MATERIALS AND METHODS:Resistin concentrations were assessed by ELISA in serum samples from 42 patients with RA. Serum samples from 38 healthy subjects acted as controls. We also evaluated the circulating levels of tumor necrosis factor- alpha (TNF-alpha) and disease activity markers in RApatients. RESULTS: In RApatients, serum resistin levels were significantly higher than those in healthy subjects. Serum resistin levels in RApatients were correlated with the RA disease activity markers, CRP and ESR. Furthermore, resistin levels in RApatients were significantly correlated with circulating levels of TNF-alpha. CONCLUSION: Serum resistin levels were significantly increased in RApatients and correlated with inflammatory markers and TNF-alpha, suggesting that resistin may play a role in the rheumatoid inflammatory process.
Authors: Jessica C Jang; Jiang Li; Luca Gambini; Hashini M Batugedara; Sandeep Sati; Mitchell A Lazar; Li Fan; Maurizio Pellecchia; Meera G Nair Journal: Proc Natl Acad Sci U S A Date: 2017-11-13 Impact factor: 11.205
Authors: Tamer A Gheita; Iman I El-Gazzar; Reem I El Shazly; Abeer M Nour El-Din; Enas Abdel-Rasheed; Rasha H Bassyouni Journal: J Clin Immunol Date: 2012-08-11 Impact factor: 8.317