OBJECTIVE: Sun exposure is the main cause of melanoma in populations of European origin. No previous study has examined the effect of sun exposure on risk of multiple primary melanomas compared with people who have one melanoma. METHODS: We identified and enrolled 2,023 people with a first primary melanoma (controls) and 1,125 with multiple primary melanomas (cases) in seven centers in four countries, recorded their residential history to assign ambient UV and interviewed them about their sun exposure. RESULTS: Risk of multiple primary melanomas increased significantly (P<0.05) to OR=2.10 for the highest exposure quarter of ambient UV irradiance at birth and 10 years of age, to OR=1.38 for lifetime recreational sun exposure, to OR=1.85 for beach and waterside activities, to OR=1.57 for vacations in a sunnier climate, to OR=1.50 for sunburns. Occupational sun exposure did not increase risk (OR=1.03 for highest exposure). Recreational exposure at any age increased risk and appeared to add to risk from ambient UV in early life. CONCLUSIONS: People who have had a melanoma can expect to reduce their risk of a further melanoma by reducing recreational sun exposure whatever their age. The same is probably true for a person who has never had a melanoma.
OBJECTIVE: Sun exposure is the main cause of melanoma in populations of European origin. No previous study has examined the effect of sun exposure on risk of multiple primary melanomas compared with people who have one melanoma. METHODS: We identified and enrolled 2,023 people with a first primary melanoma (controls) and 1,125 with multiple primary melanomas (cases) in seven centers in four countries, recorded their residential history to assign ambient UV and interviewed them about their sun exposure. RESULTS: Risk of multiple primary melanomas increased significantly (P<0.05) to OR=2.10 for the highest exposure quarter of ambient UV irradiance at birth and 10 years of age, to OR=1.38 for lifetime recreational sun exposure, to OR=1.85 for beach and waterside activities, to OR=1.57 for vacations in a sunnier climate, to OR=1.50 for sunburns. Occupational sun exposure did not increase risk (OR=1.03 for highest exposure). Recreational exposure at any age increased risk and appeared to add to risk from ambient UV in early life. CONCLUSIONS:People who have had a melanoma can expect to reduce their risk of a further melanoma by reducing recreational sun exposure whatever their age. The same is probably true for a person who has never had a melanoma.
Authors: Colin B Begg; Amanda J Hummer; Urvi Mujumdar; Bruce K Armstrong; Anne Kricker; Loraine D Marrett; Robert C Millikan; Stephen B Gruber; Hoda Anton Culver; Roberto Zanetti; Richard P Gallagher; Terrence Dwyer; Timothy R Rebbeck; Klaus Busam; Lynn From; Marianne Berwick Journal: Int J Epidemiol Date: 2006-03-23 Impact factor: 7.196
Authors: Cristina R Ferrone; Leah Ben Porat; Katherine S Panageas; Marianne Berwick; Allan C Halpern; Ami Patel; Daniel G Coit Journal: JAMA Date: 2005-10-05 Impact factor: 56.272
Authors: Elyse Shuk; Jack E Burkhalter; Carlos F Baguer; Susan M Holland; Alisa Pinkhasik; Mary Sue Brady; Daniel G Coit; Charlotte E Ariyan; Jennifer L Hay Journal: Qual Health Res Date: 2012-07
Authors: Anne Kricker; Bruce K Armstrong; Chris Goumas; Peter Kanetsky; Richard P Gallagher; Colin B Begg; Robert C Millikan; Terence Dwyer; Stefano Rosso; Loraine D Marrett; Nancy E Thomas; Marianne Berwick Journal: Cancer Causes Control Date: 2010-08-19 Impact factor: 2.506
Authors: Salina M Torres; Li Luo; Jenna Lilyquist; Christine A Stidley; Kristina Flores; Kirsten A M White; Esther Erdei; Melissa Gonzales; Susan Paine; Rachel I Vogel; Deann Lazovich; Marianne Berwick Journal: Pigment Cell Melanoma Res Date: 2013-06-03 Impact factor: 4.693
Authors: Marianne Berwick; Anne S Reiner; Susan Paine; Bruce K Armstrong; Anne Kricker; Chris Goumas; Anne E Cust; Nancy E Thomas; Pamela A Groben; Lynn From; Klaus Busam; Irene Orlow; Loraine D Marrett; Richard P Gallagher; Stephen B Gruber; Hoda Anton-Culver; Stefano Rosso; Roberto Zanetti; Peter A Kanetsky; Terry Dwyer; Alison Venn; Julia Lee-Taylor; Colin B Begg Journal: Cancer Epidemiol Biomarkers Prev Date: 2014-07-28 Impact factor: 4.254
Authors: Nancy E Thomas; Sharon N Edmiston; Irene Orlow; Peter A Kanetsky; Li Luo; David C Gibbs; Eloise A Parrish; Honglin Hao; Klaus J Busam; Bruce K Armstrong; Anne Kricker; Anne E Cust; Hoda Anton-Culver; Stephen B Gruber; Richard P Gallagher; Roberto Zanetti; Stefano Rosso; Lidia Sacchetto; Terence Dwyer; David W Ollila; Colin B Begg; Marianne Berwick; Kathleen Conway Journal: J Invest Dermatol Date: 2018-05-09 Impact factor: 8.551
Authors: Urvi J Mujumdar; Jennifer L Hay; Yvette C Monroe-Hinds; Amanda J Hummer; Colin B Begg; Homer B Wilcox; Susan A Oliveria; Marianne Berwick Journal: Psychooncology Date: 2009-10 Impact factor: 3.894