Literature DB >> 17205195

Genomic imprinting and cancer: from primordial germ cells to somatic cells.

Adele Murrell1.   

Abstract

Imprinted genes are a subset of genes that are expressed from only one of the parental alleles. The majority of imprinted genes have roles in growth regulation and are, therefore, potential oncogenes or tumour suppressors. Cancer is a disease of aberrant cell growth and is characterised by genetic mutations and epigenetic changes such as DNA methylation. The mechanisms whereby imprinting is maintained in somatic cells and then erased and reset in the germline parallels epigenetic changes that cancer cells undergo. This review summarises what we know about imprinting in stem cells and how loss of imprinting may contribute to neoplasia.

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Year:  2006        PMID： 17205195      PMCID： PMC5917277          DOI： 10.1100/tsw.2006.318

Source DB:  PubMed          Journal:  ScientificWorldJournal        ISSN： 1537-744X


  15 in total

1.  H19 imprinting control region methylation requires an imprinted environment only in the male germ line.

Authors:  Claudia Gebert; David Kunkel; Alexander Grinberg; Karl Pfeifer
Journal:  Mol Cell Biol       Date:  2009-12-28       Impact factor: 4.272

Review 2.  Specific changes in the expression of imprinted genes in prostate cancer--implications for cancer progression and epigenetic regulation.

Authors:  Teodora Ribarska; Klaus-Marius Bastian; Annemarie Koch; Wolfgang A Schulz
Journal:  Asian J Androl       Date:  2012-02-27       Impact factor: 3.285

Review 3.  Li-Fraumeni Syndrome Disease Model: A Platform to Develop Precision Cancer Therapy Targeting Oncogenic p53.

Authors:  Ruoji Zhou; An Xu; Julian Gingold; Louise C Strong; Ruiying Zhao; Dung-Fang Lee
Journal:  Trends Pharmacol Sci       Date:  2017-08-14       Impact factor: 14.819

4.  Deregulation of an imprinted gene network in prostate cancer.

Authors:  Teodora Ribarska; Wolfgang Goering; Johanna Droop; Klaus-Marius Bastian; Marc Ingenwerth; Wolfgang A Schulz
Journal:  Epigenetics       Date:  2014-02-10       Impact factor: 4.528

Review 5.  The role of genomic imprinting in biology and disease: an expanding view.

Authors:  Jo Peters
Journal:  Nat Rev Genet       Date:  2014-06-24       Impact factor: 53.242

6.  Quantitative analysis of DNA methylation at all human imprinted regions reveals preservation of epigenetic stability in adult somatic tissue.

Authors:  Kathryn Woodfine; Joanna E Huddleston; Adele Murrell
Journal:  Epigenetics Chromatin       Date:  2011-01-31       Impact factor: 4.954

7.  Loss of imprinting of insulin-like growth factor 2 is associated with increased risk of lymph node metastasis and gastric corpus cancer.

Authors:  Yang Lu; Ping Lu; Zhi Zhu; Huimian Xu; Xike Zhu
Journal:  J Exp Clin Cancer Res       Date:  2009-09-09

8.  Cohesin is required for higher-order chromatin conformation at the imprinted IGF2-H19 locus.

Authors:  Raffaella Nativio; Kerstin S Wendt; Yoko Ito; Joanna E Huddleston; Santiago Uribe-Lewis; Kathryn Woodfine; Christel Krueger; Wolf Reik; Jan-Michael Peters; Adele Murrell
Journal:  PLoS Genet       Date:  2009-11-26       Impact factor: 5.917

9.  Leukocyte DNA as surrogate for the evaluation of imprinted Loci methylation in mammary tissue DNA.

Authors:  Ludovic Barault; Rachel E Ellsworth; Holly R Harris; Allyson L Valente; Craig D Shriver; Karin B Michels
Journal:  PLoS One       Date:  2013-02-07       Impact factor: 3.240

10.  Comprehensive analyses of imprinted differentially methylated regions reveal epigenetic and genetic characteristics in hepatoblastoma.

Authors:  Janette Mareska Rumbajan; Toshiyuki Maeda; Ryota Souzaki; Kazumasa Mitsui; Ken Higashimoto; Kazuhiko Nakabayashi; Hitomi Yatsuki; Kenichi Nishioka; Ryoko Harada; Shigehisa Aoki; Kenichi Kohashi; Yoshinao Oda; Kenichiro Hata; Tsutomu Saji; Tomoaki Taguchi; Tatsuro Tajiri; Hidenobu Soejima; Keiichiro Joh
Journal:  BMC Cancer       Date:  2013-12-27       Impact factor: 4.430
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