| Literature DB >> 17204321 |
Taichi Ito1, Iain P Fraser, Yoon Yeo, Christopher B Highley, Evangelia Bellas, Daniel S Kohane.
Abstract
Postoperative peritoneal adhesions cause pelvic pain, infertility, and potentially lethal bowel obstruction. We have designed and synthesized an injectable hydrogel composed of cross-linkable modified hyaluronic acids (HAs) conjugated to dexamethasone (HAX-DEX), and investigated its anti-inflammatory function. HAX-DEX formed a hydrogel in <1min by cross-linking reactions between aldehyde groups and hydrazide groups. The hydrogel degraded in media over 5 days, releasing dexamethasone slowly over that time, reducing TNF-alpha and IL-6 production from lipopolysaccharide-stimulated primary mouse macrophages in vitro. HAX-DEX was biocompatible on subcutaneous injection, and caused less inflammation than unmodified cross-linked HA.Entities:
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Year: 2007 PMID： 17204321 DOI： 10.1016/j.biomaterials.2006.12.012
Source DB: PubMed Journal: Biomaterials ISSN： 0142-9612 Impact factor: 12.479