| Literature DB >> 17203651 |
Abstract
Unlike recombinase-mediated gene manipulations, tetracycline (Tet)-controlled genetic switches permit reversible control of gene expression in the mouse. Trancriptional activation can be induced by activators termed tTA (Tet-Off) or rtTA (Tet-On) in the absence and presence of Tet, respectively. The Tet-Off and Tet-On systems are complementary, and the decision to choose one over the other depends on the particular experimental strategy. Both systems were optimized over the years and can now be used to develop mouse models.Entities:
Mesh：
Substances：
Year: 2007 PMID： 17203651 DOI： 10.1007/978-3-540-35109-2_3
Source DB: PubMed Journal: Handb Exp Pharmacol ISSN： 0171-2004