AIM: To determine the HLA-DQ locus in Mexican patients with Chronic gastritis and gastric adenocarcinoma. METHODS: Oligotyping for HLA-DQ locus was performed in 45 Mexican patients with chronic gastritis and 13 Mexican patients with diffuse-type gastric adenocarcinoma, and was then compared with 99 clinically healthy unrelated individuals. H pylori infection and CagA status were assessed in patients by enzyme-linked immunosorbent assay (ELISA) method. RESULTS: We found a significant increased frequency of HLA-DQB1*0401 allele in H pylori-positive patients with chronic gastritis when compared with healthy subjects [19 vs 0%, P = 1 x 10(-7), odds ratio (OR) = 4.96; 95% confidence interval (95% CI), 3.87-6.35]. We also found a significant increased frequency of HLA-DQB1*0501 in patients with diffuse-type gastric carcinoma in comparison with healthy individuals (P = 1 x 10(-6), OR = 13.07; 95% CI, 2.82-85.14). CONCLUSION: HLA-DQ locus may play a different role in the development of H pylori-related chronic gastritis and diffuse-type gastric adenocarcinoma in the Mexican Mestizo population.
AIM: To determine the HLA-DQ locus in Mexican patients with Chronic gastritis and gastric adenocarcinoma. METHODS: Oligotyping for HLA-DQ locus was performed in 45 Mexican patients with chronic gastritis and 13 Mexican patients with diffuse-type gastric adenocarcinoma, and was then compared with 99 clinically healthy unrelated individuals. H pylori infection and CagA status were assessed in patients by enzyme-linked immunosorbent assay (ELISA) method. RESULTS: We found a significant increased frequency of HLA-DQB1*0401 allele in H pylori-positive patients with chronic gastritis when compared with healthy subjects [19 vs 0%, P = 1 x 10(-7), odds ratio (OR) = 4.96; 95% confidence interval (95% CI), 3.87-6.35]. We also found a significant increased frequency of HLA-DQB1*0501 in patients with diffuse-type gastric carcinoma in comparison with healthy individuals (P = 1 x 10(-6), OR = 13.07; 95% CI, 2.82-85.14). CONCLUSION:HLA-DQ locus may play a different role in the development of H pylori-related chronic gastritis and diffuse-type gastric adenocarcinoma in the Mexican Mestizo population.
Authors: T Azuma; S Ito; F Sato; Y Yamazaki; H Miyaji; Y Ito; H Suto; M Kuriyama; T Kato; Y Kohli Journal: Cancer Date: 1998-03-15 Impact factor: 6.860
Authors: M Camorlinga-Ponce; J Torres; G Perez-Perez; Y Leal-Herrera; B Gonzalez-Ortiz; A Madrazo de la Garza; A Gomez; O Muñoz Journal: Am J Gastroenterol Date: 1998-08 Impact factor: 10.864
Authors: J Torres; Y Leal-Herrera; G Perez-Perez; A Gomez; M Camorlinga-Ponce; R Cedillo-Rivera; R Tapia-Conyer; O Muñoz Journal: J Infect Dis Date: 1998-10 Impact factor: 5.226
Authors: M J Blaser; G I Perez-Perez; H Kleanthous; T L Cover; R M Peek; P H Chyou; G N Stemmermann; A Nomura Journal: Cancer Res Date: 1995-05-15 Impact factor: 12.701
Authors: X Fan; S E Crowe; S Behar; H Gunasena; G Ye; H Haeberle; N Van Houten; W K Gourley; P B Ernst; V E Reyes Journal: J Exp Med Date: 1998-05-18 Impact factor: 14.307