Rachel Yehuda1, William Blair, Ellen Labinsky, Linda M Bierer. 1. Department of Psychiatry, Mount Sinai School of Medicine and Bronx Veterans Affairs, 130 West Kingsbridge Rd., Bronx, NY 10468, USA. Rachel.Yehuda@med.va.gov
Abstract
OBJECTIVE: The authors used a low-dose dexamethasone suppression test to examine the effect of a PTSD risk factor, parental PTSD, on cortisol negative feedback inhibition in adult offspring of Holocaust survivors with PTSD (N=13) versus without PTSD (N=12) as well as a comparison group of offspring whose parents had no Holocaust exposure (N=16). METHOD: Blood samples were obtained at 8:00 a.m. for the determination of baseline cortisol. Participants ingested 0.5 mg of dexamethasone at 11:00 p.m., and blood samples were obtained again at 8:00 a.m. the following day. RESULTS: Enhanced cortisol suppression in response to dexamethasone was associated primarily with parental PTSD status, with minimal contribution of subjects' own trauma-related symptoms. CONCLUSIONS: Enhanced cortisol negative feedback inhibition may be associated with PTSD because it is related to the PTSD risk factor of parental PTSD.
OBJECTIVE: The authors used a low-dose dexamethasone suppression test to examine the effect of a PTSD risk factor, parental PTSD, on cortisol negative feedback inhibition in adult offspring of Holocaust survivors with PTSD (N=13) versus without PTSD (N=12) as well as a comparison group of offspring whose parents had no Holocaust exposure (N=16). METHOD: Blood samples were obtained at 8:00 a.m. for the determination of baseline cortisol. Participants ingested 0.5 mg of dexamethasone at 11:00 p.m., and blood samples were obtained again at 8:00 a.m. the following day. RESULTS: Enhanced cortisol suppression in response to dexamethasone was associated primarily with parental PTSD status, with minimal contribution of subjects' own trauma-related symptoms. CONCLUSIONS: Enhanced cortisol negative feedback inhibition may be associated with PTSD because it is related to the PTSD risk factor of parental PTSD.
Authors: Jill B Becker; Lisa M Monteggia; Tara S Perrot-Sinal; Russell D Romeo; Jane R Taylor; Rachel Yehuda; Tracy L Bale Journal: J Neurosci Date: 2007-10-31 Impact factor: 6.167
Authors: Amy Lehrner; Linda M Bierer; Vincent Passarelli; Laura C Pratchett; Janine D Flory; Heather N Bader; Iris R Harris; Aarti Bedi; Nikolaos P Daskalakis; Iouri Makotkine; Rachel Yehuda Journal: Psychoneuroendocrinology Date: 2013-12-01 Impact factor: 4.905