| Literature DB >> 17201650 |
Mi-Ja Kim1, Hee Jae Lee, Sumali Wiryowidagdo, Hye Kyung Kim.
Abstract
Aqueous extracts of Gynura procumbens (Lour.) Merr. were orally administered to spontaneously hypertensive (SHR) rats for 4 weeks, and antihypertensive effects were determined. Oral administration of 500 mg/kg of G. procumbens (Lour.) Merr. extract (GPE) resulted in significantly lower blood pressure in SHR rats compared with SHR rats not given GPE (P < .05). Furthermore, GPE-administered rats had significantly lower serum lactate dehydrogenase, creatine phosphate kinase, and increased nitric oxide (NO), a known vasodilator, compared with the non-GPE-administered SHR group (P < .05). These results suggest that oral administration of aqueous GPE may be useful for prevention and treatment of hypertension through increasing NO production in blood vessels.Entities:
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Year: 2006 PMID： 17201650 DOI： 10.1089/jmf.2006.9.587
Source DB: PubMed Journal: J Med Food ISSN： 1096-620X Impact factor: 2.786