UNLABELLED: The aim of this study was to investigate drug sensitivity in neuroendocrine tumor cell lines. MATERIALS AND METHODS: In vitro drug sensitivity screening was performed using the fluorometric microculture cytotoxicity assay in one human pancreatic carcinoid and two human bronchial carcinoid cell lines. In addition, a normal human retinal pigment epithelial cell line was used for comparison. A total of 18 drugs with different mechanisms of action were tested. RESULTS: The most active agents were brefeldin A, emetine, bortezomib and idarubicin, having IC5o values <1 microM in all four cell lines. In addition, the three tumor cell lines showed sensitivity for sanguinarine, Bayll-7085, mitoxantrone, doxorubicin, beta-lapachone, NSC 95397 and CGP-74514A. CONCLUSION: The cell lines were sensitive for several drugs acting in different ways, covering a broad spectrum of mechanisms of action. Some of these compounds may possibly be used in clinical trials and show therapeutic effect in patients with neuroendocrine tumors.
UNLABELLED: The aim of this study was to investigate drug sensitivity in neuroendocrine tumor cell lines. MATERIALS AND METHODS: In vitro drug sensitivity screening was performed using the fluorometric microculture cytotoxicity assay in one humanpancreatic carcinoid and two human bronchial carcinoid cell lines. In addition, a normal human retinal pigment epithelial cell line was used for comparison. A total of 18 drugs with different mechanisms of action were tested. RESULTS: The most active agents were brefeldin A, emetine, bortezomib and idarubicin, having IC5o values <1 microM in all four cell lines. In addition, the three tumor cell lines showed sensitivity for sanguinarine, Bayll-7085, mitoxantrone, doxorubicin, beta-lapachone, NSC 95397 and CGP-74514A. CONCLUSION: The cell lines were sensitive for several drugs acting in different ways, covering a broad spectrum of mechanisms of action. Some of these compounds may possibly be used in clinical trials and show therapeutic effect in patients with neuroendocrine tumors.
Authors: Meng Sun; Wei Lou; Jae Yeon Chun; Daniel S Cho; Nagalakshmi Nadiminty; Christopher P Evans; Jun Chen; Jiao Yue; Qinghua Zhou; Allen C Gao Journal: Genes Cancer Date: 2010-03
Authors: Srustidhar Das; Satyanarayana Rachagani; Maria P Torres-Gonzalez; Imayavaramban Lakshmanan; Prabin D Majhi; Lynette M Smith; Kay-Uwe Wagner; Surinder K Batra Journal: Oncotarget Date: 2015-03-20
Authors: Navneet Kumar Dubey; Bou-Yue Peng; Chien-Min Lin; Peter D Wang; Joseph R Wang; Chun-Hao Chan; Hong-Jian Wei; Win-Ping Deng Journal: Int J Mol Sci Date: 2018-05-31 Impact factor: 5.923