Literature DB >> 17200764

Alternatively spliced human tissue factor (asHTF) is not pro-coagulant.

Petra Censarek1, Anett Bobbe, Maria Grandoch, Karsten Schrör, Artur-Aron Weber.   

Abstract

It has been proposed that alternatively-spliced human tissue factor (asHTF) is pro-coagulant. We have evaluated the function of asHTF in a mammalian expression system. Full-length human tissue factor (HTF) and asHTF were cloned from smooth muscle cells and over-expressed in HEK293 cells. As expected, a marked pro-coagulant activity (FX activation, thrombin generation) was observed on the surface, in lysates, and on microparticles from HTF transfected cells. In contrast, no pro-coagulant activity of asHTF was observed.

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Year:  2007        PMID： 17200764

Source DB:  PubMed          Journal:  Thromb Haemost        ISSN： 0340-6245            Impact factor:   5.249


  15 in total

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Review 3.  Tissue factor: newer concepts in thrombosis and its role beyond thrombosis and hemostasis.

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Journal:  Cardiovasc Diagn Ther       Date:  2018-10

Review 4.  Tissue Factor and Cancer: Regulation, Tumor Growth, and Metastasis.

Authors:  Yohei Hisada; Nigel Mackman
Journal:  Semin Thromb Hemost       Date:  2019-05-16       Impact factor: 4.180

Review 5.  Pathophysiological role of blood-borne tissue factor: should the old paradigm be revisited?

Authors:  Giovanni Cimmino; Paolo Golino; Juan Jose Badimon
Journal:  Intern Emerg Med       Date:  2010-07-07       Impact factor: 3.397

6.  Interplay between alternatively spliced Tissue Factor and full length Tissue Factor in modulating coagulant activity of endothelial cells.

Authors:  B Ünlü; V Y Bogdanov; H H Versteeg
Journal:  Thromb Res       Date:  2017-05-25       Impact factor: 3.944

Review 7.  Tissue factor in coagulation: Which? Where? When?

Authors:  Saulius Butenas; Thomas Orfeo; Kenneth G Mann
Journal:  Arterioscler Thromb Vasc Biol       Date:  2009-07-10       Impact factor: 8.311

Review 8.  Tissue factor: past, present, and future.

Authors:  Nigel Mackman; Mark Taubman
Journal:  Arterioscler Thromb Vasc Biol       Date:  2009-12       Impact factor: 8.311

9.  Alternatively spliced tissue factor induces angiogenesis through integrin ligation.

Authors:  Y W van den Berg; L G van den Hengel; H R Myers; O Ayachi; E Jordanova; W Ruf; C A Spek; P H Reitsma; V Y Bogdanov; H H Versteeg
Journal:  Proc Natl Acad Sci U S A       Date:  2009-10-29       Impact factor: 11.205

Review 10.  Tissue factor, angiogenesis and tumour progression.

Authors:  Joanne E Bluff; Nicola J Brown; Malcolm W R Reed; Carolyn A Staton
Journal:  Breast Cancer Res       Date:  2008-03-17       Impact factor: 6.466
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