Literature DB >> 17200673

Epigenetic stem cell signature in cancer.

Martin Widschwendter1, Heidi Fiegl, Daniel Egle, Elisabeth Mueller-Holzner, Gilbert Spizzo, Christian Marth, Daniel J Weisenberger, Mihaela Campan, Joanne Young, Ian Jacobs, Peter W Laird.   

Abstract

Embryonic stem cells rely on Polycomb group proteins to reversibly repress genes required for differentiation. We report that stem cell Polycomb group targets are up to 12-fold more likely to have cancer-specific promoter DNA hypermethylation than non-targets, supporting a stem cell origin of cancer in which reversible gene repression is replaced by permanent silencing, locking the cell into a perpetual state of self-renewal and thereby predisposing to subsequent malignant transformation.

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Year:  2006        PMID： 17200673     DOI： 10.1038/ng1941

Source DB:  PubMed          Journal:  Nat Genet        ISSN： 1061-4036            Impact factor:   38.330


  483 in total

1.  Distinct epigenomic landscapes of pluripotent and lineage-committed human cells.

Authors:  R David Hawkins; Gary C Hon; Leonard K Lee; Queminh Ngo; Ryan Lister; Mattia Pelizzola; Lee E Edsall; Samantha Kuan; Ying Luu; Sarit Klugman; Jessica Antosiewicz-Bourget; Zhen Ye; Celso Espinoza; Saurabh Agarwahl; Li Shen; Victor Ruotti; Wei Wang; Ron Stewart; James A Thomson; Joseph R Ecker; Bing Ren
Journal:  Cell Stem Cell       Date:  2010-05-07       Impact factor: 24.633

Review 2.  Identification of driver and passenger DNA methylation in cancer by epigenomic analysis.

Authors:  Satish Kalari; Gerd P Pfeifer
Journal:  Adv Genet       Date:  2010       Impact factor: 1.944

Review 3.  Stress and the epigenetic landscape: a link to the pathobiology of human diseases?

Authors:  Sarah E Johnstone; Stephen B Baylin
Journal:  Nat Rev Genet       Date:  2010-10-05       Impact factor: 53.242

4.  DNA methylation biomarkers for lung cancer.

Authors:  Tibor A Rauch; Zunde Wang; Xiwei Wu; Kemp H Kernstine; Arthur D Riggs; Gerd P Pfeifer
Journal:  Tumour Biol       Date:  2011-12-06

Review 5.  The biology of head and neck cancer stem cells.

Authors:  Zhaocheng Zhang; Manoel Sant'Ana Filho; Jacques E Nör
Journal:  Oral Oncol       Date:  2011-11-08       Impact factor: 5.337

6.  Enzymatic assays for assessing histone deubiquitylation activity.

Authors:  Robyn T Sussman; Xiao-Yong Zhang; Steven B McMahon
Journal:  Methods       Date:  2011-04-12       Impact factor: 3.608

Review 7.  Targeting the epigenome with bioactive food components for cancer prevention.

Authors:  Thomas Prates Ong; Fernando Salvador Moreno; Sharon Ann Ross
Journal:  J Nutrigenet Nutrigenomics       Date:  2012-02-22

8.  The DNA methylation landscape of human melanoma.

Authors:  Seung-Gi Jin; Wenying Xiong; Xiwei Wu; Lu Yang; Gerd P Pfeifer
Journal:  Genomics       Date:  2015-09-15       Impact factor: 5.736

9.  Genome-wide age-related DNA methylation changes in blood and other tissues relate to histone modification, expression and cancer.

Authors:  Zongli Xu; Jack A Taylor
Journal:  Carcinogenesis       Date:  2013-11-28       Impact factor: 4.944

10.  Methylation of polycomb target genes in intestinal cancer is mediated by inflammation.

Authors:  Maria A Hahn; Torsten Hahn; Dong-Hyun Lee; R Steven Esworthy; Byung-Wook Kim; Arthur D Riggs; Fong-Fong Chu; Gerd P Pfeifer
Journal:  Cancer Res       Date:  2008-12-15       Impact factor: 12.701
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