W Hitzl1, M Stöllinger, G Grabner, H A Reitsamer, K Hornykewycz. 1. Universitätsklinik für Ophthalmologie und Optometrie, St. Johanns-Spital, Paracelsus Medizinische Privatuniversität Salzburg, Osterreich. W.Hitzl@salk.at
Abstract
BACKGROUND: This prospective, population-based longitudinal study describes prevalences and 5-year incidences of individuals with normal findings, ocular hypertension (OHT) and primary open-angle glaucoma (POAG) admitted to the Salzburg-Moorfields Collaborative Glaucoma Study (SMCGS). PATIENTS AND METHODS: The SMCGS is embedded in a government-supported glaucoma blindness prevention programme in Salzburg (Austria) which is designed for a minimum of 10-years follow-up. Each subject receives a complete ophthalmological examination. In total, the findings of 853 subjects with complete data sets were analysed and evaluated. RESULTS: The prevalence of participants with normal findings was 75 % (95 % CI: 72 - 78 %) at the initial examination, decreasing to 64 % (95 % CI: 60 - 67 %) at the 5-year follow-up. The prevalence of OHT at the initial exam of 2.3 % (95 % CI: 1.4 - 3.6 %) increased to 3.5 % (95 % CI: 2.4 - 5.0 %) at the 5-year follow-up exam with an incidence of 1.2 % (95 % CI: 0.6 - 2.2 %). Finally, the prevalence of POAG of 0.6 % (95 % CI: 0.2 - 1.4 %) increased to 1.6 % (0.9 - 2.7 %) at the 5-year exam which corresponds to a 5-year incidence of POAG of 1.0 % (0.5 - 2.0 %). CONCLUSION: The prevalence of POAG increases statistically significantly when compared at the initial and 5-year follow up exam (p = 0,002). Our results confirm the positive relation between age and the prevalence of POAG (odds ratio = 0.89, 95 % CI: 0.81 - 0.98). The prevalence and 5-year incidence rates in this glaucoma prevention study are similar to those of other population-based studies.
BACKGROUND: This prospective, population-based longitudinal study describes prevalences and 5-year incidences of individuals with normal findings, ocular hypertension (OHT) and primary open-angle glaucoma (POAG) admitted to the Salzburg-Moorfields Collaborative Glaucoma Study (SMCGS). PATIENTS AND METHODS: The SMCGS is embedded in a government-supported glaucoma blindness prevention programme in Salzburg (Austria) which is designed for a minimum of 10-years follow-up. Each subject receives a complete ophthalmological examination. In total, the findings of 853 subjects with complete data sets were analysed and evaluated. RESULTS: The prevalence of participants with normal findings was 75 % (95 % CI: 72 - 78 %) at the initial examination, decreasing to 64 % (95 % CI: 60 - 67 %) at the 5-year follow-up. The prevalence of OHT at the initial exam of 2.3 % (95 % CI: 1.4 - 3.6 %) increased to 3.5 % (95 % CI: 2.4 - 5.0 %) at the 5-year follow-up exam with an incidence of 1.2 % (95 % CI: 0.6 - 2.2 %). Finally, the prevalence of POAG of 0.6 % (95 % CI: 0.2 - 1.4 %) increased to 1.6 % (0.9 - 2.7 %) at the 5-year exam which corresponds to a 5-year incidence of POAG of 1.0 % (0.5 - 2.0 %). CONCLUSION: The prevalence of POAG increases statistically significantly when compared at the initial and 5-year follow up exam (p = 0,002). Our results confirm the positive relation between age and the prevalence of POAG (odds ratio = 0.89, 95 % CI: 0.81 - 0.98). The prevalence and 5-year incidence rates in this glaucoma prevention study are similar to those of other population-based studies.