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Literature DB >> 17198748

Induction of matrix metalloproteinases (MMP3, MMP12 and MMP13) expression in the microglia by amyloid-beta stimulation via the PI3K/Akt pathway.

Sachiko Ito¹, Kenya Kimura, Masataka Haneda, Yoshiyuki Ishida, Makoto Sawada, Ken-ichi Isobe.

Abstract

Alzheimer's disease is characterized by the presence of senile plaques in the brain composed primarily of amyloid-beta peptide. Microglia have been reported to surround these Abeta plaques, which have opposite roles, provoking a microglia-mediated inflammatory response that contributes to neuronal cell loss or the removal of Abeta and damaged neurons. We herein analyzed the process of expression of Matrix metalloproteinases induced by Abeta stimulation. We found that Abeta1-42 induces a high level of MMP3, MMP12 and MMP13 in the microglia. The signal transduction pathway for the expression of these MMPs mRNA induced by Abeta1-42 depends on PI3K/Akt.

Entities: Disease Gene

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Year: 2007 PMID： 17198748 DOI： 10.1016/j.exger.2006.11.012

Source DB: PubMed Journal: Exp Gerontol ISSN： 0531-5565 Impact factor: 4.032

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Cited

29 in total

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Journal: Acta Pharmacol Sin Date: 2011-06-20 Impact factor: 6.150

3. Spinal matrix metalloproteinase 3 mediates inflammatory hyperalgesia via a tumor necrosis factor-dependent mechanism.

Authors: C A Christianson; B L Fitzsimmons; J-H Shim; A Agrawal; S M Cohen; X-Y Hua; T L Yaksh
Journal: Neuroscience Date: 2011-10-20 Impact factor: 3.590

4. Naturally secreted amyloid-beta increases mammalian target of rapamycin (mTOR) activity via a PRAS40-mediated mechanism.

Authors: Antonella Caccamo; Monica A Maldonado; Smita Majumder; David X Medina; Walter Holbein; Andrea Magrí; Salvatore Oddo
Journal: J Biol Chem Date: 2011-01-25 Impact factor: 5.157

Induction of matrix metalloproteinases (MMP3, MMP12 and MMP13) expression in the microglia by amyloid-beta stimulation via the PI3K/Akt pathway.

1. Molecular interplay between mammalian target of rapamycin (mTOR), amyloid-beta, and Tau: effects on cognitive impairments.

2. Multiple signaling pathways involved in stimulation of osteoblast differentiation by N-methyl-D-aspartate receptors activation in vitro.

3. Spinal matrix metalloproteinase 3 mediates inflammatory hyperalgesia via a tumor necrosis factor-dependent mechanism.

4. Naturally secreted amyloid-beta increases mammalian target of rapamycin (mTOR) activity via a PRAS40-mediated mechanism.

5. Enhanced expression of matrix metalloproteinase-12 contributes to Npc1 deficiency-induced axonal degeneration.

Review 6. Targeting the mTOR signaling network for Alzheimer's disease therapy.

Review 7. Mammalian target of rapamycin (mTOR) as a potential therapeutic target in various diseases.

8. Glial Draper Rescues Aβ Toxicity in a Drosophila Model of Alzheimer's Disease.

9. MMP13 inhibition rescues cognitive decline in Alzheimer transgenic mice via BACE1 regulation.

Review 10. The role of mTOR signaling in Alzheimer disease.