| Literature DB >> 17197108 |
Arnfinn Hykkerud Steindal1, Alina Carmen Porojnicu, Johan Moan.
Abstract
Recently, we have documented that the season of diagnosis affects the prognosis of Hodgkin's lymphoma, colon-, breast- and prostate-cancer patients in Norway. The relative risk of death was lower for the patients diagnosed during summer and autumn when compared with the winter diagnosis. We here hypothesise that UV (ultraviolet) induced degradation of folate may be the reason for the observed seasonal variations in cancer prognosis. It is known that folic acid, a synthetic form of folate, is degraded by UV radiation. We have also found that the most common folate derivative in the human body, 5-methyltetrahydrofolate, is UV sensitive.Entities:
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Year: 2007 PMID： 17197108 DOI： 10.1016/j.mehy.2006.07.063
Source DB: PubMed Journal: Med Hypotheses ISSN： 0306-9877 Impact factor: 1.538