Literature DB >> 1719677

The dopamine hypothesis of the reinforcing properties of cocaine.

M J Kuhar1, M C Ritz, J W Boja.   

Abstract

A variety of evidence suggests a 'dopamine hypothesis' for the reinforcing properties of cocaine. This hypothesis proposes that cocaine binds at the dopamine transporter and mainly inhibits neurotransmitter re-uptake; the resulting potentiation of dopaminergic neurotransmission in mesolimbocortical pathways ultimately causes reinforcement. This model suggests potential medications for treatment of cocaine abuse and dependence. Some, but not all, pharmacological data in humans support the hypothesis and additional experimentation is needed.

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Year:  1991        PMID： 1719677     DOI： 10.1016/0166-2236(91)90141-g

Source DB:  PubMed          Journal:  Trends Neurosci        ISSN： 0166-2236            Impact factor:   13.837


  220 in total

1.  Preferential increases in nucleus accumbens dopamine after systemic cocaine administration are caused by unique characteristics of dopamine neurotransmission.

Authors:  Q Wu; M E Reith; M J Kuhar; F I Carroll; P A Garris
Journal:  J Neurosci       Date:  2001-08-15       Impact factor: 6.167

2.  The dopamine transporter: comparative ultrastructure of dopaminergic axons in limbic and motor compartments of the nucleus accumbens.

Authors:  M J Nirenberg; J Chan; A Pohorille; R A Vaughan; G R Uhl; M J Kuhar; V M Pickel
Journal:  J Neurosci       Date:  1997-09-15       Impact factor: 6.167

3.  Examination of a role for metabotropic glutamate receptor 5 in the medial prefrontal cortex in cocaine sensitization in rats.

Authors:  Kristin M Timmer; Jeffery D Steketee
Journal:  Psychopharmacology (Berl)       Date:  2011-11-16       Impact factor: 4.530

4.  Role of serotonin in cocaine effects in mice with reduced dopamine transporter function.

Authors:  Yolanda Mateo; Evgeny A Budygin; Carrie E John; Sara R Jones
Journal:  Proc Natl Acad Sci U S A       Date:  2003-12-22       Impact factor: 11.205

5.  Singular value decomposition analysis of the torsional angles of dopamine reuptake inhibitor GBR 12909 analogs: effect of force field and charges.

Authors:  Deepangi Pandit; Anna Fiorentino; Supreet Bindra; Carol A Venanzi
Journal:  J Mol Model       Date:  2010-09-14       Impact factor: 1.810

6.  Cocaine binding sites in fetal rat brain: implications for prenatal cocaine action.

Authors:  J S Meyer; L P Shearman; L M Collins; R L Maguire
Journal:  Psychopharmacology (Berl)       Date:  1993       Impact factor: 4.530

7.  Paradoxical abatement of striatal dopaminergic transmission by cocaine and methylphenidate.

Authors:  Mauro Federici; Emanuele Claudio Latagliata; Ada Ledonne; Francesca R Rizzo; Marco Feligioni; Dave Sulzer; Matthew Dunn; Dalibor Sames; Howard Gu; Robert Nisticò; Stefano Puglisi-Allegra; Nicola B Mercuri
Journal:  J Biol Chem       Date:  2013-11-26       Impact factor: 5.157

8.  Effects of ( R)-Modafinil and Modafinil Analogues on Dopamine Dynamics Assessed by Voltammetry and Microdialysis in the Mouse Nucleus Accumbens Shell.

Authors:  Jacqueline D Keighron; Juliana C Quarterman; Jianjing Cao; Emily M DeMarco; Mark A Coggiano; Apre Gleaves; Rachel D Slack; Claudio Zanettini; Amy Hauck Newman; Gianluigi Tanda
Journal:  ACS Chem Neurosci       Date:  2019-01-31       Impact factor: 4.418

9.  Concurrent cocaine-ethanol ingestion in humans: pharmacology, physiology, behavior, and the role of cocaethylene.

Authors:  E F McCance-Katz; L H Price; C J McDougle; T R Kosten; J E Black; P I Jatlow
Journal:  Psychopharmacology (Berl)       Date:  1993       Impact factor: 4.530

Review 10.  Development of the dopamine transporter selective RTI-336 as a pharmacotherapy for cocaine abuse.

Authors:  F Ivy Carroll; James L Howard; Leonard L Howell; Barbara S Fox; Michael J Kuhar
Journal:  AAPS J       Date:  2006-03-24       Impact factor: 4.009
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