Literature DB >> 17196681

Genealogy of centenarians and their relatives: a study of 12 families.

M Motta1, M Malaguarnera, E Ferrari, V Nicita Mauro, L Ferrucci, R Rapisarda, F B Tomasello, G Basile, L Ferlito, M Passamonte, E Bennati.   

Abstract

The longevity is a complex phenomenon in which specific genetic properties seem to play a role. The present study intended to reconstruct the genealogical tree of 12 subjects, being residents of one Northern and one Southern province of Italy, in order to establish the longevity of the ancestors. Detailed studies have been performed in the registry offices and the historic archives. The research method started from the identification of the centenarians on the basis of the documentation of the relevant birth document, it was continued by identifying the documents of birth, marriages and death of the parents of the centenarians. This way we proceeded systematically backwards in time. In addition, we verified the medium life span of the Italian population in the given periods of time, when the centenarians and their ascending lines had lived. These results offer clear historic-statistical evidences for the genetic basis of longevity.

Mesh:

Year:  2006        PMID: 17196681      PMCID: PMC2646091          DOI: 10.1016/j.archger.2006.10.004

Source DB:  PubMed          Journal:  Arch Gerontol Geriatr        ISSN: 0167-4943            Impact factor:   3.250


  6 in total

1.  Life-long sustained mortality advantage of siblings of centenarians.

Authors:  Thomas T Perls; John Wilmoth; Robin Levenson; Maureen Drinkwater; Melissa Cohen; Hazel Bogan; Erin Joyce; Stephanie Brewster; Louis Kunkel; Annibale Puca
Journal:  Proc Natl Acad Sci U S A       Date:  2002-06-11       Impact factor: 11.205

2.  Analysis of hemochromatosis gene mutations in the Sicilian population: implications for survival and longevity.

Authors:  C R Balistreri; G Candore; P Almasio; V Di Marco; G Colonna-Romano; A Craxi; M Motta; G Piazza; M Malaguarnera; D Lio; C Caruso
Journal:  Arch Gerontol Geriatr Suppl       Date:  2002

3.  The heritability of CHD mortality in danish twins after controlling for smoking and BMI.

Authors:  Andreas Wienke; Anne M Herskind; Kaare Christensen; Axel Skytthe; Anatoli I Yashin
Journal:  Twin Res Hum Genet       Date:  2005-02       Impact factor: 1.587

4.  A genome-wide scan for linkage to human exceptional longevity identifies a locus on chromosome 4.

Authors:  A A Puca; M J Daly; S J Brewster; T C Matise; J Barrett; M Shea-Drinkwater; S Kang; E Joyce; J Nicoli; E Benson; L M Kunkel; T Perls
Journal:  Proc Natl Acad Sci U S A       Date:  2001-08-27       Impact factor: 11.205

Review 5.  T cells and aging, January 2002 update.

Authors:  Graham Pawelec; Yvonne Barnett; Ros Forsey; Daniela Frasca; Amiela Globerson; Julie McLeod; Calogero Caruso; Claudio Franceschi; Támás Fülöp; Sudhir Gupta; Erminia Mariani; Eugenio Mocchegiani; Rafael Solana
Journal:  Front Biosci       Date:  2002-05-01

6.  Mitochondrial DNA inherited variants are associated with successful aging and longevity in humans.

Authors:  G De Benedictis; G Rose; G Carrieri; M De Luca; E Falcone; G Passarino; M Bonafe; D Monti; G Baggio; S Bertolini; D Mari; R Mattace; C Franceschi
Journal:  FASEB J       Date:  1999-09       Impact factor: 5.191

  6 in total
  3 in total

Review 1.  Optimal therapy of type 2 diabetes: a controversial challenge.

Authors:  Angela Dardano; Giuseppe Penno; Stefano Del Prato; Roberto Miccoli
Journal:  Aging (Albany NY)       Date:  2014-03       Impact factor: 5.682

Review 2.  A gut-centric view of aging: Do intestinal epithelial cells contribute to age-associated microbiota changes, inflammaging, and immunosenescence?

Authors:  Leah S Hohman; Lisa C Osborne
Journal:  Aging Cell       Date:  2022-08-24       Impact factor: 11.005

3.  Centenarians and supercentenarians: a black swan. Emerging social, medical and surgical problems.

Authors:  Marco Vacante; Velia D'Agata; Massimo Motta; Giulia Malaguarnera; Antonio Biondi; Francesco Basile; Michele Malaguarnera; Caterina Gagliano; Filippo Drago; Salvatore Salamone
Journal:  BMC Surg       Date:  2012-11-15       Impact factor: 2.102

  3 in total

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