| Literature DB >> 17196387 |
Georg Jaeschke1, Richard Porter, Bernd Büttelmann, Simona M Ceccarelli, Wolfgang Guba, Bernd Kuhn, Sabine Kolczewski, Jörg Huwyler, Vincent Mutel, Jens-Uwe Peters, Theresa Ballard, Eric Prinssen, Eric Vieira, Jürgen Wichmann, Will Spooren.
Abstract
Optimization of affinity and microsomal stability led to identification of the potent, metabolically stable fenobam analog 4l. Robust in vivo efficacy of 4l was demonstrated in four different models of anxiety. Additionally, a ligand based pharmacophore alignment of fenobam and MPEP is proposed.Entities:
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Year: 2006 PMID： 17196387 DOI： 10.1016/j.bmcl.2006.12.033
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823