| Literature DB >> 17196385 |
Adrian Hall1, Stephen Atkinson, Susan H Brown, Iain P Chessell, Anita Chowdhury, Gerard M P Giblin, Paul Goldsmith, Mark P Healy, Karamjit S Jandu, Matthew R Johnson, Anton D Michel, Alan Naylor, Jennifer A Sweeting.
Abstract
Replacement of the carboxylic acid group in a series of previously described 1,5-biaryl pyrrole EP1 receptor antagonists led to the discovery of various novel non-acidic antagonists. Several analogues displayed high binding affinity and high binding efficiency indices.Entities:
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Year: 2006 PMID： 17196385 DOI： 10.1016/j.bmcl.2006.12.021
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823