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Literature DB >> 17196194

Self-administration of cocaine-antihistamine combinations: super-additive reinforcing effects.

Abstract

Histamine H1 receptor antagonists have some behavioral effects that predict abuse liability. In the present study, diphenhydramine and cocaine each maintained i.v. self-administration under a progressive-ratio schedule in rhesus monkeys. When cocaine and DPH were combined in a 1:1 ratio of the ED50s, the combination was super-additive in all monkeys. The data predict that the combination of cocaine and histamine H1 receptor antagonists would have enhanced potential for abuse relative to either drug alone.

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Year: 2006 PMID： 17196194 PMCID： PMC1847370 DOI： 10.1016/j.ejphar.2006.11.056

Source DB: PubMed Journal: Eur J Pharmacol ISSN： 0014-2999 Impact factor: 4.432

7 in total

1. Discriminative stimulus properties of histamine H1-antagonists in animals trained to discriminate d-amphetamine or pentobarbital.

Authors: S M Evans; C E Johanson
Journal: J Pharmacol Exp Ther Date: 1989-09 Impact factor: 4.030

2. On the relationship between the dopamine transporter and the reinforcing effects of local anesthetics in rhesus monkeys: practical and theoretical concerns.

Authors: K M Wilcox; J K Rowlett; I A Paul; G A Ordway; W L Woolverton
Journal: Psychopharmacology (Berl) Date: 2000-12 Impact factor: 4.530

3. Histamine excites GABAergic cells in the rat substantia nigra and ventral tegmental area in vitro.

Authors: Tatiana M Korotkova; Helmut L Haas; Ritchie E Brown
Journal: Neurosci Lett Date: 2002-03-08 Impact factor: 3.046

4. Effects of fexofenadine, diphenhydramine, and alcohol on driving performance. A randomized, placebo-controlled trial in the Iowa driving simulator.

Authors: J M Weiler; J R Bloomfield; G G Woodworth; A R Grant; T A Layton; T L Brown; D R McKenzie; T W Baker; G S Watson
Journal: Ann Intern Med Date: 2000-03-07 Impact factor: 25.391

5. Increased levels of extracellular dopamine in neostriatum and nucleus accumbens after histamine H1 receptor blockade.

Authors: H C Dringenberg; M A de Souza-Silva; R K Schwarting; J P Huston
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1998-10 Impact factor: 3.000

6. The intravenous self-administration of antihistamines by rhesus monkeys.

Authors: P M Beardsley; R L Balster
Journal: Drug Alcohol Depend Date: 1992-06 Impact factor: 4.492

7. Effects of the combination of tripelennamine and pentazocine at the behavioral and molecular levels.

Authors: H E Shannon; T P Su
Journal: Pharmacol Biochem Behav Date: 1982-10 Impact factor: 3.533

7 in total

6 in total

Self-administration of cocaine-antihistamine combinations: super-additive reinforcing effects.

1. Discriminative stimulus properties of histamine H1-antagonists in animals trained to discriminate d-amphetamine or pentobarbital.

2. On the relationship between the dopamine transporter and the reinforcing effects of local anesthetics in rhesus monkeys: practical and theoretical concerns.

3. Histamine excites GABAergic cells in the rat substantia nigra and ventral tegmental area in vitro.

4. Effects of fexofenadine, diphenhydramine, and alcohol on driving performance. A randomized, placebo-controlled trial in the Iowa driving simulator.

5. Increased levels of extracellular dopamine in neostriatum and nucleus accumbens after histamine H1 receptor blockade.

6. The intravenous self-administration of antihistamines by rhesus monkeys.

7. Effects of the combination of tripelennamine and pentazocine at the behavioral and molecular levels.

1. Self-administration of cocaine-pentobarbital mixtures by rhesus monkeys.

2. Self-administration of drug mixtures by monkeys: combining drugs with comparable mechanisms of action.

3. Super-additive interaction of the reinforcing effects of cocaine and H1-antihistamines in rhesus monkeys.

4. Behavioral and neurochemical effects of cocaine and diphenhydramine combinations in rhesus monkeys.

5. Evaluation of the Reinforcing Effect of Quetiapine, Alone and in Combination with Cocaine, in Rhesus Monkeys.

6. Self-administration of cocaine-remifentanil mixtures by monkeys: an isobolographic analysis.