Literature DB >> 17195868

The antiapoptotic RBM5/LUCA-15/H37 gene and its role in apoptosis and human cancer: research update.

Mirna M Maarabouni1, Gwyn T Williams.   

Abstract

The candidate tumour-suppressor gene, LUCA-15/RBM5/H37, maps to the lung cancer tumour-suppressor locus 3p21.3. The LUCA-15 gene locus encodes at least four alternatively spliced transcripts that have been shown to function as regulators of apoptosis, a fact which may have major significance in tumour regulation. This review highlights recent evidence that further implicates the LUCA-15 locus in the control of apoptosis and cell proliferation, and focuses on the observations that confirm the tumour-suppressor activity of this gene.

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Year:  2006        PMID： 17195868      PMCID： PMC1825760          DOI： 10.1100/tsw.2006.268

Source DB:  PubMed          Journal:  ScientificWorldJournal        ISSN： 1537-744X


  45 in total

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Journal:  Curr Opin Cell Biol       Date:  1997-12       Impact factor: 8.382

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Journal:  Mol Cell Biol       Date:  1997-06       Impact factor: 4.272

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Journal:  Cancer Res       Date:  1999-04-15       Impact factor: 12.701

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Journal:  Oncogene       Date:  1999-04-22       Impact factor: 9.867

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Journal:  Proc Natl Acad Sci U S A       Date:  1999-03-02       Impact factor: 11.205

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Journal:  Cancer Res       Date:  1998-03-01       Impact factor: 12.701

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Journal:  Genes Chromosomes Cancer       Date:  1997-11       Impact factor: 5.006
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  6 in total

1.  Targeting zinc finger domains with small molecules: solution structure and binding studies of the RanBP2-type zinc finger of RBM5.

Authors:  Biancamaria Farina; Roberto Fattorusso; Maurizio Pellecchia
Journal:  Chembiochem       Date:  2011-12-16       Impact factor: 3.164

2.  Overexpression of RBM5 induces autophagy in human lung adenocarcinoma cells.

Authors:  Zhenzhong Su; Ke Wang; Ranwei Li; Jinzhi Yin; Yuqiu Hao; Xuejiao Lv; Junyao Li; Lijing Zhao; Yanwei Du; Ping Li; Jie Zhang
Journal:  World J Surg Oncol       Date:  2016-02-29       Impact factor: 2.754

3.  Differential expression of RBM5 and KRAS in pancreatic ductal adenocarcinoma and their association with clinicopathological features.

Authors:  Jie Peng; Ali Kord Valeshabad; Qingfu Li; Yuan Wang
Journal:  Oncol Lett       Date:  2012-12-17       Impact factor: 2.967

4.  The tumor suppressor gene RBM5 inhibits lung adenocarcinoma cell growth and induces apoptosis.

Authors:  Chen Shao; Lijing Zhao; Ke Wang; Wei Xu; Jie Zhang; Baoxue Yang
Journal:  World J Surg Oncol       Date:  2012-08-06       Impact factor: 2.754

5.  3p21.3 tumor suppressor gene RBM5 inhibits growth of human prostate cancer PC-3 cells through apoptosis.

Authors:  Lijing Zhao; Ranwei Li; Chen Shao; Ping Li; Jian Liu; Ke Wang
Journal:  World J Surg Oncol       Date:  2012-11-16       Impact factor: 2.754

6.  RBM-5 modulates U2AF large subunit-dependent alternative splicing in C. elegans.

Authors:  Chuanman Zhou; Xiaoyang Gao; Surong Hu; Wenjing Gan; Jing Xu; Yongchao C Ma; Long Ma
Journal:  RNA Biol       Date:  2018-10-13       Impact factor: 4.652
  6 in total

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