BACKGROUND AND PURPOSE: The relationship between diabetic retinopathy and ischemic stroke is uncertain and examined in this study. METHODS: A population-based, prospective cohort study of 1617 middle-aged persons with diabetes. Diabetic retinopathy signs were ascertained from retinal photographs, and incident ischemic stroke events were prospectively identified and validated. RESULTS: Over an average follow-up of 7.8 years, there were 75 ischemic stroke events. After adjustment for age, gender, race, center, 6-year mean arterial blood pressure, anti-hypertensive treatment use, fasting glucose, insulin treatment, duration of diabetes, high-density lipoprotein and low-density lipoprotein cholesterol levels and cigarette smoking status, diabetic retinopathy was associated with an increased risk of ischemic stroke (hazard rate ratio, 2.34; 95% CI, 1.13 to 4.86). CONCLUSIONS: Diabetic retinopathy predicts incident ischemic stroke in people with diabetes, independent of other risk factors.
BACKGROUND AND PURPOSE: The relationship between diabetic retinopathy and ischemic stroke is uncertain and examined in this study. METHODS: A population-based, prospective cohort study of 1617 middle-aged persons with diabetes. Diabetic retinopathy signs were ascertained from retinal photographs, and incident ischemic stroke events were prospectively identified and validated. RESULTS: Over an average follow-up of 7.8 years, there were 75 ischemic stroke events. After adjustment for age, gender, race, center, 6-year mean arterial blood pressure, anti-hypertensive treatment use, fasting glucose, insulin treatment, duration of diabetes, high-density lipoprotein and low-density lipoprotein cholesterol levels and cigarette smoking status, diabetic retinopathy was associated with an increased risk of ischemic stroke (hazard rate ratio, 2.34; 95% CI, 1.13 to 4.86). CONCLUSIONS:Diabetic retinopathy predicts incident ischemic stroke in people with diabetes, independent of other risk factors.
Authors: Ning Cheung; Sophie Rogers; Thomas H Mosley; Ronald Klein; David Couper; Tien Y Wong Journal: Psychosom Med Date: 2008-12-10 Impact factor: 4.312
Authors: Yash R Patel; M Sue Kirkman; Robert V Considine; Tamara S Hannon; Kieren J Mather Journal: J Diabetes Complications Date: 2016-11-12 Impact factor: 2.852
Authors: Patrice M Hicks; Samuel A Collazo Melendez; Albert Vitale; William Self; Mary Elizabeth Hartnett; Paul Bernstein; Denise J Morgan; Michael Feehan; Akbar Shakoor; Ivana Kim; Leah A Owen; Margaret M DeAngelis Journal: J Community Med Public Health Date: 2019-06-10
Authors: Ryo Kawasaki; Ning Cheung; F M Amirul Islam; Ronald Klein; Barbara E K Klein; Mary Frances Cotch; A Richey Sharrett; Daniel O'Leary; Tien Y Wong Journal: Ophthalmology Date: 2010-12-18 Impact factor: 12.079