| Literature DB >> 17194642 |
Delphine Lavens1, Julie Piessevaux, Jan Tavernier.
Abstract
Leptin was discovered as an adipostat, regulating body weight by balancing food intake and energy expenditure. Recently, leptin emerged as a pleiotropic cytokine. It plays a substantial role in a wide spectrum of other functions including immune regulation, bone formation and fertility. Leptin signalling is under tight control. Aberrations of this stringent control system may be implicated in a variety of pathologies. Here, we review the various mechanisms that control cellular leptin receptor signalling.Entities:
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Year: 2006 PMID： 17194642
Source DB: PubMed Journal: Eur Cytokine Netw ISSN： 1148-5493 Impact factor: 2.737