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Literature DB >> 17194606

Xenopus as a model system for vertebrate heart development.

Abstract

The African clawed frog, Xenopus laevis, is a valuable model system for studies of vertebrate heart development. In the following review, we describe a range of embryological and molecular methodologies that are used in Xenopus research and discuss key discoveries relating to heart development that have been made using this model system. We also discuss how the sequence of the Xenopus tropicalis genome provides a valuable tool for identification of orthologous genes and for identification of evolutionarily conserved promoter elements. Finally, both forward and reverse genetic approaches are currently being applied to Xenopus for the study of vertebrate heart development.

Entities: Species

Mesh：

Year: 2006 PMID： 17194606 PMCID： PMC1868678 DOI： 10.1016/j.semcdb.2006.11.010

Source DB: PubMed Journal: Semin Cell Dev Biol ISSN： 1084-9521 Impact factor: 7.727

63 in total

1. Amphibian cardiac troponin I gene's organization, developmental expression, and regulatory properties are different from its mammalian homologue.

Authors: Andrew S Warkman; Burr G Atkinson
Journal: Dev Dyn Date: 2004-02 Impact factor: 3.780

2. Induction of cardiomyocytes by GATA4 in Xenopus ectodermal explants.

Authors: Branko V Latinkić; Surendra Kotecha; Timothy J Mohun
Journal: Development Date: 2003-08 Impact factor: 6.868

3. Vital dye mapping of the gastrula and neurula of Xenopus laevis. II. Prospective areas and morphogenetic movements of the deep layer.

Authors: R E Keller
Journal: Dev Biol Date: 1976-07-01 Impact factor: 3.582

4. Transgenic Xenopus laevis strain expressing cre recombinase in muscle cells.

Authors: Christoph Waldner; Kazuhiro Sakamaki; Naoto Ueno; Gülüzar Turan; Gerhart U Ryffel
Journal: Dev Dyn Date: 2006-08 Impact factor: 3.780

5. Transgenic analysis of the atrialnatriuretic factor (ANF) promoter: Nkx2-5 and GATA-4 binding sites are required for atrial specific expression of ANF.

Authors: Eric M Small; Paul A Krieg
Journal: Dev Biol Date: 2003-09-01 Impact factor: 3.582

6. Defining a large set of full-length clones from a Xenopus tropicalis EST project.

Authors: Michael J Gilchrist; Aaron M Zorn; Jana Voigt; James C Smith; Nancy Papalopulu; Enrique Amaya
Journal: Dev Biol Date: 2004-07-15 Impact factor: 3.582

7. Transcriptional regulation of the cardiac-specific MLC2 gene during Xenopus embryonic development.

Authors: Branko V Latinkic; Brian Cooper; Stuart Smith; Surendra Kotecha; Norma Towers; Duncan Sparrow; Timothy J Mohun
Journal: Development Date: 2004-01-07 Impact factor: 6.868

8. The mouse muscle creatine kinase promoter faithfully drives reporter gene expression in transgenic Xenopus laevis.

Authors: Wayland Lim; Eric S Neff; J David Furlow
Journal: Physiol Genomics Date: 2004-06-17 Impact factor: 3.107

9. Controlling transgene expression to study Xenopus laevis metamorphosis.

Authors: Biswajit Das; Donald D Brown
Journal: Proc Natl Acad Sci U S A Date: 2004-03-26 Impact factor: 11.205

10. Regulation of heart size in Xenopus laevis.

Authors: Robert J Garriock; Thomas A Drysdale
Journal: Differentiation Date: 2003-10 Impact factor: 3.880

39 in total

1. Wnt/beta-catenin signalling regulates cardiomyogenesis via GATA transcription factors.

Authors: Jennifer Martin; Boni A Afouda; Stefan Hoppler
Journal: J Anat Date: 2010-01 Impact factor: 2.610

Review 2. Cardiac developmental toxicity.

Authors: Gretchen J Mahler; Jonathan T Butcher
Journal: Birth Defects Res C Embryo Today Date: 2011-12

10. Absence of heartbeat in the Xenopus tropicalis mutation muzak is caused by a nonsense mutation in cardiac myosin myh6.

Authors: Anita Abu-Daya; Amy K Sater; Dan E Wells; Timothy J Mohun; Lyle B Zimmerman
Journal: Dev Biol Date: 2009-09-19 Impact factor: 3.582

Xenopus as a model system for vertebrate heart development.

1. Amphibian cardiac troponin I gene's organization, developmental expression, and regulatory properties are different from its mammalian homologue.

2. Induction of cardiomyocytes by GATA4 in Xenopus ectodermal explants.

3. Vital dye mapping of the gastrula and neurula of Xenopus laevis. II. Prospective areas and morphogenetic movements of the deep layer.

4. Transgenic Xenopus laevis strain expressing cre recombinase in muscle cells.

5. Transgenic analysis of the atrialnatriuretic factor (ANF) promoter: Nkx2-5 and GATA-4 binding sites are required for atrial specific expression of ANF.

6. Defining a large set of full-length clones from a Xenopus tropicalis EST project.

7. Transcriptional regulation of the cardiac-specific MLC2 gene during Xenopus embryonic development.

8. The mouse muscle creatine kinase promoter faithfully drives reporter gene expression in transgenic Xenopus laevis.

9. Controlling transgene expression to study Xenopus laevis metamorphosis.

10. Regulation of heart size in Xenopus laevis.

1. Wnt/beta-catenin signalling regulates cardiomyogenesis via GATA transcription factors.

Review 2. Cardiac developmental toxicity.

3. New doxycycline-inducible transgenic lines in Xenopus.

4. An interspecies heart-to-heart: Using Xenopus to uncover the genetic basis of congenital heart disease.

Review 5. Xenopus as a model organism for birth defects-Congenital heart disease and heterotaxy.

6. Embryonic Stem Cells as a Model for Cardiac Development and Disease.

7. SHP-2 is required for the maintenance of cardiac progenitors.

8. Gaussian process post-processing for particle tracking velocimetry.

9. Axial Skeletal Malformations in Genetically Modified Xenopus laevis and Xenopus tropicalis.

10. Absence of heartbeat in the Xenopus tropicalis mutation muzak is caused by a nonsense mutation in cardiac myosin myh6.