| Literature DB >> 17194598 |
Kanchan Kothari1, Sudhanand Prasad, Aruna Korde, Archana Mukherjee, Archana Mathur, Manu Jaggi, Meera Venkatesh, Ambikalmajan M R Pillai, Rama Mukherjee, Natesan Ramamoorthy.
Abstract
Vasoactive intestinal peptide (VIP) receptors are expressed abundantly on many types of tumors and, hence, radiolabeled VIP analogues are being explored for tumor imaging and therapy. Here, we report synthesis of three VIP analogues and their radiolabeling with (99m)Tc via a novel tricarbonyl synthon. The radiolabeled product could be prepared in high yields (>95%) and stability. In vitro studies showed significant uptake of (99m)Tc(CO)((3))-VP05 in human colon carcinoma cells. Biodistribution studies in animal tumor model showed 0.4-1%ID/g tumor uptake.Entities:
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Year: 2006 PMID： 17194598 DOI： 10.1016/j.apradiso.2006.11.001
Source DB: PubMed Journal: Appl Radiat Isot ISSN： 0969-8043 Impact factor: 1.513