Literature DB >> 17193222

A pair of novel cytotoxic polyprenylated xanthone epimers from gamboges.

Quan-Bin Han1, Ling Yang, Yu-Lin Wang, Chun-Feng Qiao, Jing-Zheng Song, Han-Dong Sun, Hong-Xi Xu.   

Abstract

Two new polyprenylated xanthone epimers were isolated from gamboges of Garcinia hanburyi, and identified by detailed spectroscopic analysis as 30-hydroxygambogic acid (2a) and its (2S)-epimer 30-hydroxyepigambogic acid (2b). Both compounds exhibited significant cytotoxicities against the human leukemia K562/S and the corresponding doxorubicin-resistant K562/R cell lines (Table 2).

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Year:  2006        PMID: 17193222     DOI: 10.1002/cbdv.200690000

Source DB:  PubMed          Journal:  Chem Biodivers        ISSN: 1612-1872            Impact factor:   2.408


  2 in total

Review 1.  Recent research on bioactive xanthones from natural medicine: Garcinia hanburyi.

Authors:  Buyun Jia; Shanshan Li; Xuerui Hu; Guangyu Zhu; Weidong Chen
Journal:  AAPS PharmSciTech       Date:  2015-07-08       Impact factor: 3.246

2.  2-Phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl 3-oxide Radical (PTIO•) Trapping Activity and Mechanisms of 16 Phenolic Xanthones.

Authors:  Xican Li; Ban Chen; Xiaojun Zhao; Dongfeng Chen
Journal:  Molecules       Date:  2018-07-11       Impact factor: 4.411

  2 in total

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