| Literature DB >> 17193204 |
Hongxia Ding1, Wei Lu, Haibo Li, Leixiang Yang, Qijun Zhang, Changxin Zhou, Xiumei Wu, Olivier Baudoin, Junchao Cai, Françoise Guéritte, Yu Zhao.
Abstract
Novel compounds designed as hybrids of 1-arylnaphthalene lignans with isoquinoline alkaloids were prepared and evaluated for their cytotoxicities on human tumor cell lines, such as A549, Hela, PC-3, CNE, BEL-7404, and KB. Some of the synthetic compounds exhibited their IC50 values on selected cell lines at 10(-6) M scale. The preliminary CoMFA molecular-modelling studies of these synthetic analogues were also performed.Entities:
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Year: 2005 PMID： 17193204 DOI： 10.1002/cbdv.200590092
Source DB: PubMed Journal: Chem Biodivers ISSN： 1612-1872 Impact factor: 2.408