Literature DB >> 17193198

Antileishmanial physalins from Physalis minima.

M Iqbal Choudhary1, Sammer Yousaf, Shakil Ahmed, Kauser Yasmeen.   

Abstract

Three new physalins (1-3) and a new withanolide 7 have been isolated from the whole plant of Physalis minima, along with three known physalins: physalin H (4), isophysalin B (5), and 5beta,6beta-epoxyphysalin B (6). Their structures were deduced on the basis of in-depth spectroscopic analyses. Compounds 1-6 showed significant in vitro leishmanicidal activities (0.92-19.4 microg/ml) against promastigotes of Leishmania major.

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Year:  2005        PMID： 17193198     DOI： 10.1002/cbdv.200590086

Source DB:  PubMed          Journal:  Chem Biodivers        ISSN： 1612-1872            Impact factor:   2.408


  5 in total

Review 1.  Therapeutic Applications of Physalins: Powerful Natural Weapons.

Authors:  Cássio Santana Meira; José Waldson Capinan Soares; Bruna Padilha Zurita Claro Dos Reis; Luciano Vasconcellos Pacheco; Ivanilson Pimenta Santos; Dahara Keyse Carvalho Silva; Julia Costa de Lacerda; Sérgio Ricardo Teixeira Daltro; Elisalva Teixeira Guimarães; Milena Botelho Pereira Soares
Journal:  Front Pharmacol       Date:  2022-04-05       Impact factor: 5.988

2.  New withanolides from Physalis minima and their cytotoxicity against A375 human melanoma cells.

Authors:  Meng Zhang; Bingyang Zhang; Chenxi Guang; Benke Jiang; Xinya He; Shijie Cao; Liqin Ding; Ning Kang; Lixia Chen; Feng Qiu
Journal:  RSC Adv       Date:  2020-06-16       Impact factor: 4.036

3.  Importance of ROS-mediated autophagy in determining apoptotic cell death induced by physapubescin B.

Authors:  Jian Xu; Yihua Wu; Guang Lu; Shujun Xie; Zhongjun Ma; Zhe Chen; Han-Ming Shen; Dajing Xia
Journal:  Redox Biol       Date:  2017-02-24       Impact factor: 11.799

4.  Physalins V-IX, 16,24-cyclo-13,14-seco withanolides from Physalis angulata and their antiproliferative and anti-inflammatory activities.

Authors:  Cheng-Peng Sun; Chong-Yue Qiu; Feng Zhao; Ning Kang; Li-Xia Chen; Feng Qiu
Journal:  Sci Rep       Date:  2017-06-22       Impact factor: 4.379

5.  Leishmanicidal Activity of Withanolides from Aureliana Fasciculata var. Fasciculata.

Authors:  Simone Cristina de M Lima; Juliana da Silva Pacheco; André M Marques; Eduardo Raul Pereira Veltri; Rita de Cássia Almeida-Lafetá; Maria Raquel Figueiredo; Maria Auxiliadora Coelho Kaplan; Eduardo Caio Torres-Santos
Journal:  Molecules       Date:  2018-11-30       Impact factor: 4.411
  5 in total

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