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Literature DB >> 17192654

The role of the cytoskeleton in neuromuscular junction formation.

G Clement Dobbins¹, Bin Zhang, Wen C Xiong, Lin Mei.

Abstract

The cytoskeleton plays a vital role in neuromuscular junction (NMJ) formation. It is responsible for shaping synaptic membrane into folds opposed to presynaptic active zones and anchoring acetylcholine receptors (AChRs) to the crest of the junctional folds. Acetylcholine receptors (AChRs) associate with the actin cytoskeleton, the disruption of which affects spontaneous and agrin-induced AChR clusters (Prives et al., 1982; Connolly, 1984; Peng and Phelan, 1984; Bloch, 1986; Dai et al., 2000). How AChRs are tethered to the actin cytoskeleton remains unclear.

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Year: 2006 PMID： 17192654 DOI： 10.1385/JMN:30:1:115

Source DB: PubMed Journal: J Mol Neurosci ISSN： 0895-8696 Impact factor: 3.444

23 in total

1. The actin-driven movement and formation of acetylcholine receptor clusters.

Authors: Z Dai; X Luo; H Xie; H B Peng
Journal: J Cell Biol Date: 2000-09-18 Impact factor: 10.539

2. Agrin regulates rapsyn interaction with surface acetylcholine receptors, and this underlies cytoskeletal anchoring and clustering.

Authors: Martijn Moransard; Lucia S Borges; Raffaella Willmann; P Angelo Marangi; Hans Rudolf Brenner; Michael J Ferns; Christian Fuhrer
Journal: J Biol Chem Date: 2002-12-16 Impact factor: 5.157

3. Determination of the tissue distributions and relative concentrations of the postsynaptic 43-kDa protein and the acetylcholine receptor in Torpedo.

Authors: W J LaRochelle; S C Froehner
Journal: J Biol Chem Date: 1986-04-25 Impact factor: 5.157

4. Rapsyn may function as a link between the acetylcholine receptor and the agrin-binding dystrophin-associated glycoprotein complex.

Authors: E D Apel; S L Roberds; K P Campbell; J P Merlie
Journal: Neuron Date: 1995-07 Impact factor: 17.173

5. Crosslinking of proteins in acetylcholine receptor-rich membranes: association between the beta-subunit and the 43 kd subsynaptic protein.

Authors: S J Burden; R L DePalma; G S Gottesman
Journal: Cell Date: 1983-12 Impact factor: 41.582

6. Failure of postsynaptic specialization to develop at neuromuscular junctions of rapsyn-deficient mice.

Authors: M Gautam; P G Noakes; J Mudd; M Nichol; G C Chu; J R Sanes; J P Merlie
Journal: Nature Date: 1995-09-21 Impact factor: 49.962

Review 7. Congenital myasthenic syndromes: A diverse array of molecular targets.

Authors: Andrew G Engel; Kinji Ohno; Steven M Sine
Journal: J Neurocytol Date: 2003 Jun-Sep

8. The rotational diffusion of the acetylcholine receptor in Torpeda marmorata membrane fragments studied with a spin-labelled alpha-toxin: importance of the 43 000 protein(s).

Authors: A Rousselet; J Cartaud; P F Devaux; J P Changeux
Journal: EMBO J Date: 1982 Impact factor: 11.598

9. Interaction of the cytoskeletal framework with acetylcholine receptor on th surface of embryonic muscle cells in culture.

Authors: J Prives; A B Fulton; S Penman; M P Daniels; C N Christian
Journal: J Cell Biol Date: 1982-01 Impact factor: 10.539

Review 6. ROCK inhibition as a therapy for spinal muscular atrophy: understanding the repercussions on multiple cellular targets.

Authors: Emmanuelle Coque; Cédric Raoul; Mélissa Bowerman
Journal: Front Neurosci Date: 2014-08-28 Impact factor: 4.677

6 in total

The role of the cytoskeleton in neuromuscular junction formation.

1. The actin-driven movement and formation of acetylcholine receptor clusters.

2. Agrin regulates rapsyn interaction with surface acetylcholine receptors, and this underlies cytoskeletal anchoring and clustering.

3. Determination of the tissue distributions and relative concentrations of the postsynaptic 43-kDa protein and the acetylcholine receptor in Torpedo.

4. Rapsyn may function as a link between the acetylcholine receptor and the agrin-binding dystrophin-associated glycoprotein complex.

5. Crosslinking of proteins in acetylcholine receptor-rich membranes: association between the beta-subunit and the 43 kd subsynaptic protein.

6. Failure of postsynaptic specialization to develop at neuromuscular junctions of rapsyn-deficient mice.

Review 7. Congenital myasthenic syndromes: A diverse array of molecular targets.

8. The rotational diffusion of the acetylcholine receptor in Torpeda marmorata membrane fragments studied with a spin-labelled alpha-toxin: importance of the 43 000 protein(s).

9. Interaction of the cytoskeletal framework with acetylcholine receptor on th surface of embryonic muscle cells in culture.

10. Actin at receptor-rich domains of isolated acetylcholine receptor clusters.

1. Podosomes are present in a postsynaptic apparatus and participate in its maturation.

2. Coronin 6 regulates acetylcholine receptor clustering through modulating receptor anchorage to actin cytoskeleton.

3. Dystroglycan versatility in cell adhesion: a tale of multiple motifs.

4. Fasudil improves survival and promotes skeletal muscle development in a mouse model of spinal muscular atrophy.

5. Internalization of Muscle-Specific Kinase Is Increased by Agrin and Independent of Kinase-Activity, Lrp4 and Dynamin.

Review 6. ROCK inhibition as a therapy for spinal muscular atrophy: understanding the repercussions on multiple cellular targets.