Literature DB >> 17192642

Phenotype comparison of three acetylcholinesterase knockout strains.

Ellen G Duysen1, Oksana Lockridge.   

Abstract

The phenotypes of three mouse strains that carry the acetylcholinesterase knockout (AChE KO) mutation have been compared. The AChE KO mouse was developed from embryonic stem (ES) cells, originating from a 129/Sv blastocyst. Animals generated from strain 129/Sv suffer from dysgenesis of the corpus callosum and possibly a number of other neuroanatomical deficiencies. To determine the contribution of background genes to phenotype, 129/Sv AChE heterozygote (AChE+/-) mice were backcrossed 10 generations with wild-type inbred C57/BL6 (C57) mice and with wild-type outbred CD1(R) mice. AChE-/- mice in strains C57 and CD1died during seizures before postnatal day (P) 21, whereas mice in strain 129/Sv lived to adulthood.

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Year:  2006        PMID： 17192642     DOI： 10.1385/JMN:30:1:91

Source DB:  PubMed          Journal:  J Mol Neurosci        ISSN： 0895-8696            Impact factor:   3.444


  1 in total

1.  Rescue of the acetylcholinesterase knockout mouse by feeding a liquid diet; phenotype of the adult acetylcholinesterase deficient mouse.

Authors:  Ellen G Duysen; Judith A Stribley; Debra L Fry; Steven H Hinrichs; Oksana Lockridge
Journal:  Brain Res Dev Brain Res       Date:  2002-07-30
  1 in total
  6 in total

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2.  Altered sensitivity of cerebellar granule cells to glutamate receptor overactivation in the Cln3(Δex7/8)-knock-in mouse model of juvenile neuronal ceroid lipofuscinosis.

Authors:  Rozzy Finn; Attila D Kovács; David A Pearce
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3.  Targeting of acetylcholinesterase in neurons in vivo: a dual processing function for the proline-rich membrane anchor subunit and the attachment domain on the catalytic subunit.

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Journal:  J Neurosci       Date:  2009-04-08       Impact factor: 6.167

4.  Finding the most appropriate mouse model of juvenile CLN3 (Batten) disease for therapeutic studies: the importance of genetic background and gender.

Authors:  Attila D Kovács; David A Pearce
Journal:  Dis Model Mech       Date:  2015-04       Impact factor: 5.758

5.  The deletion of M4 muscarinic receptors increases motor activity in females in the dark phase.

Authors:  Paulina Valuskova; Sandor T Forczek; Vladimir Farar; Jaromir Myslivecek
Journal:  Brain Behav       Date:  2018-07-06       Impact factor: 2.708

6.  Synthesis and Bioactivity Evaluation of a Novel 1,2,4-Oxadiazole Derivative in vitro and in 3×Tg Mice.

Authors:  Zhuohui Luo; Yongcheng Wang; Shuo Pang; Shan Gao; Ning Liu; Xiang Gao; Li Zhang; Xiaolong Qi; Yajun Yang; Lianfeng Zhang
Journal:  Drug Des Devel Ther       Date:  2022-09-25       Impact factor: 4.319
  6 in total

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