Literature DB >> 17192086

Total synthesis and biological evaluation of verticipyrone and analogues.

Hiroyuki Shimamura1, Toshiaki Sunazuka, Takashi Izuhara, Tomoyasu Hirose, Kazuro Shiomi, Satoshi Omura.   

Abstract

[reaction: see text] Total synthesis of verticipyrone, a novel NADH-fumarate reductase inhibitor, has been accomplished by a convergent approach using novel "Reverse Julia olefination" method. During total synthetic studies, we also prepared and evaluated several synthetic verticipyrone analogues, some of which exhibited more potent antiparasitic activity than the natural verticipyrone.

Entities:  

Mesh：

Substances：

Year:  2007        PMID： 17192086     DOI： 10.1021/ol0626140

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  6 in total

1.  Synthesis and evaluation of verticipyrone analogues as mitochondrial complex I inhibitors.

Authors:  Simon J Leiris; Omar M Khdour; Zachary J Segerman; Krystal S Tsosie; Jean-Charles Chapuis; Sidney M Hecht
Journal:  Bioorg Med Chem       Date:  2010-03-31       Impact factor: 3.641

2.  Mechanism and stereospecificity of a fully saturating polyketide synthase module: nanchangmycin synthase module 2 and its dehydratase domain.

Authors:  Xun Guo; Tiangang Liu; Chiara R Valenzano; Zixin Deng; David E Cane
Journal:  J Am Chem Soc       Date:  2010-10-27       Impact factor: 15.419

3.  Synthesis and SAR of Lehualide B: a marine-derived natural product with potent anti-multiple myeloma activity.

Authors:  Valer Jeso; Chunying Yang; Michael D Cameron; John L Cleveland; Glenn C Micalizio
Journal:  ACS Chem Biol       Date:  2013-04-02       Impact factor: 5.100

4.  Essential role of the donor acyl carrier protein in stereoselective chain translocation to a fully reducing module of the nanchangmycin polyketide synthase.

Authors:  Xun Guo; Tiangang Liu; Zixin Deng; David E Cane
Journal:  Biochemistry       Date:  2012-01-17       Impact factor: 3.162

5.  Novel, male-produced aggregation pheromone of the cerambycid beetle Rosalia alpina, a priority species of European conservation concern.

Authors:  Alenka Žunič Kosi; Yunfan Zou; Michal Hoskovec; Al Vrezec; Nataša Stritih; Jocelyn G Millar
Journal:  PLoS One       Date:  2017-08-21       Impact factor: 3.240

6.  Nocapyrones: α- and γ-pyrones from a marine-derived Nocardiopsis sp.

Authors:  Youngju Kim; Hiromu Ogura; Kazuaki Akasaka; Tsutomu Oikawa; Nobuyasu Matsuura; Chiaki Imada; Hisato Yasuda; Yasuhiro Igarashi
Journal:  Mar Drugs       Date:  2014-07-08       Impact factor: 5.118
  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.