Literature DB >> 17191979

Antiplasmodial activity of naphthoquinones related to lapachol and beta-lapachone.

Elisa Pérez-Sacau1, Ana Estévez-Braun, Angel G Ravelo, David Gutiérrez Yapu, Alberto Giménez Turba.   

Abstract

The in vitro antiplasmodial activity of 26 naphthoquinone derivatives related to the natural lapachol (1) and beta-lapachone (2) was tested. Ten of these derivatives are reported for the first time. The evaluation was performed on cultures of F32 strain of Plasmodium falciparum, and some derivatives displayed attractive in vitro activities (IC50 < 10 microM). Based on these results, some structure-activity relationships have been determined.

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Year:  2005        PMID： 17191979     DOI： 10.1002/cbdv.200590009

Source DB:  PubMed          Journal:  Chem Biodivers        ISSN： 1612-1872            Impact factor:   2.745


  9 in total

1.  In vitro electrical-stimulated wound-healing chip for studying electric field-assisted wound-healing process.

Authors:  Yung-Shin Sun; Shih-Wei Peng; Ji-Yen Cheng
Journal:  Biomicrofluidics       Date:  2012-09-05       Impact factor: 2.800

2.  Synthesis, SAR, and Docking Studies Disclose 2-Arylfuran-1,4-naphthoquinones as In Vitro Antiplasmodial Hits.

Authors:  Tatiane Freitas Borgati; Maria Fernanda Alves do Nascimento; Juma Fortunato Bernardino; Lunamaura Claudia Oliveira Martins; Alex Gutterres Taranto; Alaíde Braga de Oliveira
Journal:  J Trop Med       Date:  2017-10-31

3.  Efficient Synthesis and Antimicrobial Evaluation of Pyrazolopyranopyrimidines in the Presence of SBA-Pr-SO3H as a Nanoporous Acid Catalyst.

Authors:  Ghodsi Mohammadi Ziarani; Faezeh Aleali; Negar Lashgari; Alireza Badiei; Ali Abolhasani Soorki
Journal:  Iran J Pharm Res       Date:  2018       Impact factor: 1.696

4.  Synthesis and evaluation of antimicrobial activity, cytotoxic and pro-apoptotic effects of novel spiro-4H-pyran derivatives.

Authors:  Fatemeh Safari; Hajar Hosseini; Mohammad Bayat; Ashkan Ranjbar
Journal:  RSC Adv       Date:  2019-08-09       Impact factor: 4.036

5.  Pantothenamides are potent, on-target inhibitors of Plasmodium falciparum growth when serum pantetheinase is inactivated.

Authors:  Christina Spry; Cristiano Macuamule; Zhiyang Lin; Kristopher G Virga; Richard E Lee; Erick Strauss; Kevin J Saliba
Journal:  PLoS One       Date:  2013-02-06       Impact factor: 3.240

6.  Synthetic 1,4-pyran naphthoquinones are potent inhibitors of dengue virus replication.

Authors:  Emmerson C B da Costa; Raquel Amorim; Fernando C da Silva; David R Rocha; Michelle P Papa; Luciana B de Arruda; Ronaldo Mohana-Borges; Vitor F Ferreira; Amilcar Tanuri; Luciana J da Costa; Sabrina B Ferreira
Journal:  PLoS One       Date:  2013-12-20       Impact factor: 3.240

Review 7.  Chiral Alkyl Halides: Underexplored Motifs in Medicine.

Authors:  Bálint Gál; Cyril Bucher; Noah Z Burns
Journal:  Mar Drugs       Date:  2016-11-04       Impact factor: 5.118

8.  Effects of a novel β-lapachone derivative on Trypanosoma cruzi: Parasite death involving apoptosis, autophagy and necrosis.

Authors:  Danielle Oliveira Dos Anjos; Eliomara Sousa Sobral Alves; Vinicius Tomaz Gonçalves; Sheila Suarez Fontes; Mateus Lima Nogueira; Ana Márcia Suarez-Fontes; João Batista Neves da Costa; Fabricio Rios-Santos; Marcos André Vannier-Santos
Journal:  Int J Parasitol Drugs Drug Resist       Date:  2016-10-12       Impact factor: 4.284

9.  Synthesis and Antiplasmodial Activity of 1,2,3-Triazole-Naphthoquinone Conjugates.

Authors:  Sandra Oramas-Royo; Priscila López-Rojas; Ángel Amesty; David Gutiérrez; Ninoska Flores; Patricia Martín-Rodríguez; Leandro Fernández-Pérez; Ana Estévez-Braun
Journal:  Molecules       Date:  2019-10-30       Impact factor: 4.411
  9 in total

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