Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Antimalarial constituents from Nauclea orientalis (L.) L.

Literature DB >> 17191939

Antimalarial constituents from Nauclea orientalis (L.) L.

Zhen-Dan He¹, Cui-Ying Ma, Hong-Jie Zhang, Ghee Teng Tan, Pamela Tamez, Kongmany Sydara, S Bouamanivong, Bounhoong Southavong, Djaja D Soejarto, John M Pezzuto, Harry H S Fong.

Abstract

Bioassay-guided fractionation of the antimalarial-active CHCl3 extract of the dried stem of Nauclea orientalis (L.) L. (Rubiaceae) has resulted in the isolation of two novel tetrahydro-beta-carboline monoterpene alkaloid glucosides, naucleaorine (= (16alpha,17beta)-3,14:15,20-tetradehydro-16-ethenyl-17-(beta-D-glucopyranosyloxy)-19alpha-methoxyoxayohimban-21-one; 1) and epimethoxynaucleaorine (2), as well as the known compounds, strictosidine lactam (= (15beta,16alpha,17beta)-19,20-didehydro-16-ethenyl-17-(beta-D-glucopyranosyloxy)oxayohimban-21-one; 3), 3,4,5-trimethoxyphenol (4), 3alpha-hydroxyurs-12-en-28-oic acid methyl ester (5), 3alpha,23-dihydroxyurs-12-en-28-oic acid (6), 3alpha,19alpha,23-trihydroxyurs-12-en-28-oic acid methyl ester (7), and oleanolic acid (8). Compounds 1, 2, 6, and 8 showed moderate in vitro activities against Plasmodium falciparum. Their structures and configurations were elucidated by spectroscopic methods including 1D- and 2D-NMR analyses.

Entities: Chemical Species

Mesh：

Substances：
Antimalarials

Year: 2005 PMID： 17191939 DOI： 10.1002/cbdv.200590110

Source DB: PubMed Journal: Chem Biodivers ISSN： 1612-1872 Impact factor: 2.408

Keyword Cloud
Cited

9 in total

1. An ethnobotanical survey of medicinal plants of Laos toward the discovery of bioactive compounds as potential candidates for pharmaceutical development.

Authors: D D Soejarto; C Gyllenhaal; M R Kadushin; B Southavong; K Sydara; S Bouamanivong; M Xaiveu; H-J Zhang; S G Franzblau; Ghee T Tan; J M Pezzuto; M C Riley; B G Elkington; D P Waller
Journal: Pharm Biol Date: 2011-12-02 Impact factor: 3.503

2. Two antiproliferative triterpene saponins from Nematostylis anthophylla from the highlands of Central Madagascar.

Authors: Yumin Dai; Liva Harinantenaina; Peggy J Brodie; Chris Birkinshaw; Richard Randrianaivo; Wendy Applequist; Michel Ratsimbason; Vincent E Rasamison; Yongchun Shen; Karen TenDyke; David G I Kingston
Journal: Chem Biodivers Date: 2013-02 Impact factor: 2.408

3. Ethnobotanical approach versus random approach in the search for new bioactive compounds: support of a hypothesis.

Authors: C Gyllenhaal; M R Kadushin; B Southavong; K Sydara; S Bouamanivong; M Xaiveu; L T Xuan; N T Hiep; N V Hung; P K Loc; L X Dac; T Q Bich; N M Cuong; H M Ly; H J Zhang; S G Franzblau; H Xie; M C Riley; B G Elkington; H T Nguyen; D P Waller; C Y Ma; P Tamez; G T Tan; J M Pezzuto; D D Soejarto
Journal: Pharm Biol Date: 2012-01 Impact factor: 3.503

4. Bioactive small-molecule constituents of Lao plants.

Authors: Yulin Ren; Bethany G Elkington; Joshua M Henkin; Kongmany Sydara; A Douglas Kinghorn; Djaja D Soejarto
Journal: J Med Plant Res Date: 2021-12-31

Review 5. Indigenous Uses, Phytochemical Analysis, and Anti-Inflammatory Properties of Australian Tropical Medicinal Plants.

Authors: Karma Yeshi; Gerry Turpin; Tenzin Jamtsho; Phurpa Wangchuk
Journal: Molecules Date: 2022-06-15 Impact factor: 4.927

6. Revisiting the linkage between ethnomedical use and development of new medicines: A novel plant collection strategy towards the discovery of anticancer agents.

Authors: Joshua M Henkin; Kongmany Sydara; Mouachanh Xayvue; Onevilay Souliya; A Douglas Kinghorn; Joanna E Burdette; Wei-Lun Chen; Bethany G Elkington; Djaja D Soejarto
Journal: J Med Plant Res Date: 2017-10-25

Antimalarial constituents from Nauclea orientalis (L.) L.

1. An ethnobotanical survey of medicinal plants of Laos toward the discovery of bioactive compounds as potential candidates for pharmaceutical development.

2. Two antiproliferative triterpene saponins from Nematostylis anthophylla from the highlands of Central Madagascar.

3. Ethnobotanical approach versus random approach in the search for new bioactive compounds: support of a hypothesis.

4. Bioactive small-molecule constituents of Lao plants.

Review 5. Indigenous Uses, Phytochemical Analysis, and Anti-Inflammatory Properties of Australian Tropical Medicinal Plants.

6. Revisiting the linkage between ethnomedical use and development of new medicines: A novel plant collection strategy towards the discovery of anticancer agents.

Review 7. Analysis of additivity and synergism in the anti-plasmodial effect of purified compounds from plant extracts.

Review 8. Antimalarial Activity of Plant Metabolites.

9. Yellow Twig (Nauclea&nbsp;orientalis) from Thailand: Strictosamide as the Key Alkaloid of This Plant Species.

Antimalarial constituents from Nauclea orientalis (L.) L.

1. An ethnobotanical survey of medicinal plants of Laos toward the discovery of bioactive compounds as potential candidates for pharmaceutical development.

2. Two antiproliferative triterpene saponins from Nematostylis anthophylla from the highlands of Central Madagascar.

3. Ethnobotanical approach versus random approach in the search for new bioactive compounds: support of a hypothesis.

4. Bioactive small-molecule constituents of Lao plants.

Review 5. Indigenous Uses, Phytochemical Analysis, and Anti-Inflammatory Properties of Australian Tropical Medicinal Plants.

6. Revisiting the linkage between ethnomedical use and development of new medicines: A novel plant collection strategy towards the discovery of anticancer agents.

Review 7. Analysis of additivity and synergism in the anti-plasmodial effect of purified compounds from plant extracts.

Review 8. Antimalarial Activity of Plant Metabolites.

9. Yellow Twig (Nauclea&amp;nbsp;orientalis) from Thailand: Strictosamide as the Key Alkaloid of This Plant Species.

9. Yellow Twig (Nauclea orientalis) from Thailand: Strictosamide as the Key Alkaloid of This Plant Species.