The search for new fragrance ingredients for functional perfumery.

Functional perfumery is an integral part of the fragrance business. It demands that the ingredients chosen for compounding withstand the aggressive nature of some of the bases used for soaps, detergents, softeners, bleach, and personal-care products. The synthetic efforts in this area reported in this short personal account, presented in a talk at the RSC/SCI conference Flavours & Fragrances 2004 (Manchester), have resulted in the discovery of the two new proprietary molecules Fleuranil (5/6) and Khusinil (7), which fulfill the criteria of functional perfumery. The structure-odor relationships of several analogs of Fleuranil and Khusinil prepared in the course of these investigations are also presented.